Mixtures of cannabinoid compounds, and production and use thereof

Patent metadata

Field	Value
Publication number	US-9670133-B2
Application number	US-201414653044-A
Country	US
Kind code	B2
Filing date	Jun 30, 2014
Priority date	Sep 3, 2013
Publication date	Jun 6, 2017
Grant date	Jun 6, 2017

Abstract

Specific compositions comprising one or multiple (cannabinoid) compound(s) of formula (A) and/or one or multiple salt(s) thereof are described as well as methods for their manufacture.

A compound of formula (A), a salt of formula (A) and a respective composition for use as medicine and for use in a method for the therapeutic treatment of the human or animal body, respectively, are also described.
Furthermore, corresponding pharmaceutical formulations, cosmetic preparations and foodstuff and/or gourmet or snack preparations fit for consumption as well as a method for the manufacture of delta-9-tetrahydrocannabinol are described.

First claim

The invention claimed is:

1. A compound selected from the group consisting of:

or a salt thereof.

2. A composition comprising one or more compounds and/or salts of claim 1 .

3. A pharmaceutical composition comprising one or more compounds and/or salts of claim 1 .

4. A method for manufacturing a compound of claim 1 comprising converting menthadienol with an olivetolic acid ester to derive the compound.

5. A method for manufacturing cannabidiol comprising:
(a) obtaining a compound or salt of claim 1 ; and
(b) subjecting the compound or salt to saponification and decarboxylation to generate cannabidiol.

6. A composition comprising:
(a) one or more compounds selected from the group consisting of:

 or a salt thereof;
(b) optionally, cannabidiol, wherein if cannabidiol is present, the ratio of the total amount of the one or more compounds of (a) and/or salts thereof to the total amount of cannabidiol is greater than 1:1; and
(c) optionally, a compound of Formula (I)

wherein if a compound of Formula (I) is present, the ratio of the total amount of the one or more compounds of (a) and/or salts thereof to the total amount of the compound of Formula (I) is greater than 1:1.

7. A medicine comprising a composition of claim 6 .

8. A method for the therapeutic treatment of a human or animal comprising administering a composition of claim 6 to the human or animal, wherein the therapeutic treatment provides:
an appetite-stimulating effect,
an anti-emetic effect to inhibit nausea and vomiting,
reduction of muscular cramps and spasticity,
alleviation of pain symptoms,
alleviation of migraine symptoms,
reduction of intraocular pressure related to glaucoma,
mood enhancement,
immunostimulation, and/or
antiepileptic effect.

9. A method for manufacturing a composition of claim 6 comprising converting menthadienol with one or more olivetolic acid esters to derive the one or more compounds and/or salts of (a) in the composition.

10. A method for manufacturing cannabidiol comprising:
(a) preparing a composition of claim 6 ; and
(b) subjecting the one or more compounds of (a) and/or salts in the composition to saponification and decarboxylation to generate cannabidiol.

Assignees

• Symrise Ag

Inventors

• Koch Oskar
• Götz Marcus Rudolf
• Looft Jan
• Vössing Tobias

Classifications

• A61P37/04

  Immunostimulants · CPC title

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P25/06

  Antimigraine agents · CPC title

• A61P25/24

  Antidepressants · CPC title

• A61P25/04

  Centrally acting analgesics, e.g. opioids · CPC title