Microchip

Patent metadata

Field	Value
Publication number	US-9669407-B2
Application number	US-201113292699-A
Country	US
Kind code	B2
Filing date	Nov 9, 2011
Priority date	Nov 12, 2010
Publication date	Jun 6, 2017
Grant date	Jun 6, 2017

Abstract

Disclosed herein is a microchip that allows a sample to be introduced into a region easily and accurately, and which makes it possible to obtain high analysis accuracy. The microchip includes an airtight region into which a solution is externally introduced; and positioning means for positioning a channel for injecting the solution into the region by penetrating a substrate layer forming the region with respect to a puncture part of the region.

First claim

The application is claimed as follows:

1. A microchip comprising:
a main body that comprises a first substrate layer laminated to a second substrate layer, and an airtight region between the laminated first and second substrate layers, wherein the airtight region has a pressure lower than an atmospheric pressure; and
a frame body mounted to the main body,
wherein the frame body comprises an arm,
wherein the first substrate layer of the main body includes a sealing portion that extends from an outer surface of the first substrate layer to a puncture part in the airtight region, wherein the first substrate layer is configured to have a self-sealing characteristic due to elastic deformation, and
wherein the arm of the frame body includes a positioning hole,
wherein the positioning hole is configured for alignment above the puncture part in the airtight region, and
wherein the positioning hole is smaller than the area of the airtight region.

2. The microchip according to claim 1 , wherein the frame body includes a plurality of arms, wherein each arm of the plurality of arms contacts one of an upper surface or a lower surface of the main body.

3. The microchip according to claim 2 ,
wherein the opening is in one of the plurality of arms, and
wherein the plurality of arms are biased against the upper surface and the lower surface of the main body to support the main body between the plurality of arms.

4. The microchip according to claim 1 , wherein the airtight region in the main body includes at least one elongated flow path that extends away from the puncture part, and at least one well positioned along a length of the at least one elongated flow path.

5. The microchip according to claim 1 , wherein the airtight region in the main body includes a plurality of flow paths that extends away from the puncture part.

6. The microchip according to claim 1 , wherein the first substrate layer is of a material selected from a silicone base elastomer, an acrylic base elastomer, a urethane base elastomer, a fluorine base elastomer, a styrene base elastomer, an epoxy base elastomer or a natural rubber.

7. The microchip according to claim 1 , wherein the first substrate layer and the second substrate layer are of materials that are optically transparent and auto fluorescent.

8. The microchip according to claim 1 , wherein the pressure of the airtight region is about 1/100 of the atmospheric pressure.

Assignees

• Kojima Kensuke
• Segawa Yuji
• Watanabe Hidetoshi
• Kato Yoshiaki
• Watanabe Toshio
• Sony Corp

Inventors

• Kojima Kensuke
• Segawa Yuji
• Watanabe Hidetoshi
• Kato Yoshiaki
• Watanabe Toshio

Classifications

• B01L3/502715 Primary

  characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces · CPC title

• B01L2300/0609

  Holders integrated in container to position an object · CPC title

• B01L2300/0816

  Cards, e.g. flat sample carriers usually with flow in two horizontal directions · CPC title

• B01L2200/0684

  Venting, avoiding backpressure, avoid gas bubbles · CPC title

• B01L2300/043

  Hinged closures · CPC title