Infusion sets for the delivery of a therapeutic substance to a patient

Patent metadata

Field	Value
Publication number	US-9669156-B2
Application number	US-201615237174-A
Country	US
Kind code	B2
Filing date	Aug 15, 2016
Priority date	Dec 28, 2005
Publication date	Jun 6, 2017
Grant date	Jun 6, 2017

Abstract

Devices and methods for delivering a therapeutic substance to a patient are provided. Embodiments include infusion sets that include an active agent. Also provided are systems and kits.

First claim

What is claimed is:

1. A method of using an infusion system comprising an inner cannula configured to deliver a medication to a patient and an outer cannula configured to reside over the inner cannula and to deliver the medication to the patient, wherein the method comprises:
positioning the inner cannula and the outer cannula together under the skin of the patient;
using one of the inner cannula or the outer cannula to deliver the medication to the patient;
withdrawing the used cannula from the patient while leaving the other cannula within the patient to deliver the medication; and
delivering the medication through the other cannula.

2. The method of claim 1 , wherein the medication is insulin.

3. The method of claim 2 , wherein using one of the inner cannula or the outer cannula to deliver the medication to the patient comprises using one of the inner cannula or the outer cannula to deliver the insulin into subcutaneous tissue of the patient.

4. The method of claim 1 , comprising:
using the inner cannula to deliver the medication to the patient;
withdrawing the inner cannula from the patient while leaving the outer cannula within the patient; and
then delivering the medication through the outer cannula.

5. The method of claim 4 , wherein the inner and outer cannulas are coupled with an on-body device that is also coupled with a sensor, the method comprising:
positioning the sensor in the patient; and
sensing an analyte level of the patient with the sensor.

6. The method of claim 5 , wherein the infusion system comprises a pump and a sensor control unit in electrical communication with the sensor, wherein the pump is configured to automatically receive information indicative of the analyte level from the sensor control unit.

7. The method of claim 4 , wherein positioning the inner cannula and the outer cannula together under the skin of the patient comprises positioning an end of the inner cannula and an end of the outer cannula under the skin of the patient, wherein the end of the inner cannula is at a greater depth under the skin than the end of the outer cannula.

8. The method of claim 1 , comprising:
using the outer cannula to deliver the medication to the patient;
withdrawing the outer cannula from the patient while leaving the inner cannula within the patient; and
then delivering the medication through the inner cannula.

9. The method of claim 8 , wherein the inner and outer cannulas are coupled with an on-body device that is also coupled with a sensor, the method comprising:
positioning the sensor in the patient; and
sensing an analyte level of the patient with the sensor.

10. The method of claim 9 , wherein the infusion system comprises a pump and a sensor control unit in electrical communication with the sensor, wherein the pump is configured to automatically receive information indicative of the analyte level from the sensor control unit.

11. The method of claim 8 , wherein positioning the inner cannula and the outer cannula together under the skin of the patient comprises positioning an end of the inner cannula and an end of the outer cannula under the skin of the patient, wherein the end of the outer cannula is at a greater depth under the skin than the end of the inner cannula.

12. The method of claim 1 , wherein the infusion system further comprises a securement element and an implantable sensor for monitoring an analyte level, the method comprising securing the implantable sensor, the inner cannula, and the outer cannula to the patient with the securement element.

13. The method of claim 1 , wherein the infusion set further comprises tubing configured for fluid communication between a source of the medication and the inner or outer cannula.

14. The method of claim 1 , wherein an active agent comprising an anti-scarring agent or both an antimicrobial agent and an anti-scarring agent is present on at least one component of the infusion system.

15. The method of claim 14 , further comprising controllably releasing the active agent over a predetermined time period by use of a non-active agent.

16. The method of claim 15 , wherein the non-active agent comprises a polymer.

17. The method of claim 16 , wherein the polymer partially degrades or disintegrates over the predetermined time period to release the active agent.

18. The method of claim 15 , wherein the non-active agent provides a diffusion layer between the patient and the inner or outer cannula.

19. The method of claim 15 , wherein the active agent is present on the outer cannula.

20. The method of claim 15 , wherein the active agent is present on an outer surface of the outer cannula and on an outer surface of the inner cannula.

Assignees

• Abbott Diabetes Care Inc

Inventors

• Jennewine R Curtis

Classifications

• A61B5/150389

  Hollow piercing elements, e.g. canulas, needles, for piercing the skin · CPC title

• A61B5/150022

  for capillary blood or interstitial fluid · CPC title

• A61B5/150969

  Low-profile devices which resemble patches or plasters, e.g. also allowing collection of blood samples for testing · CPC title

• A61M37/00

  Other apparatus for introducing media into the body (for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30); Percutany, i.e. introducing medicines into the body by diffusion through the skin (salt baths A61H33/04) · CPC title

• A61B5/14532 Primary

  for measuring glucose, e.g. by tissue impedance measurement · CPC title