A novel acylated insulin analog
US-2024374692-A1 · Nov 14, 2024 · US
Use of proinsulin for immune system modulation
US9669073B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9669073-B2 |
| Application number | US-201514674590-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 31, 2015 |
| Priority date | Dec 30, 2014 |
| Publication date | Jun 6, 2017 |
| Grant date | Jun 6, 2017 |
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Abstract
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The present disclosure relates to a composition for promoting immune activity including a protein selected from the group consisting of dimeric proinsulin, C-peptide partially deleted mutant of dimeric proinsulin, and C-peptide partially deleted mutant of monomeric proinsulin as an effective component and a composition for immunosuppression including C-peptide site of proinsulin as an effective component, and the dimeric proinsulin, the C-peptide partially deleted mutant of dimeric proinsulin, and the C-peptide partially deleted mutant of monomeric proinsulin can be applied as immune enhancers to diabetic patients.
First claim
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What is claimed is: 1. A method of promoting immune activity in a patient, comprising administering a protein selected from the group consisting of a dimeric proinsulin and a dimeric proinsulin mutant with C-peptide partially deleted to the patient in need thereof, wherein the dimeric proinsulin mutant with C-peptide partially deleted is a dimer of a peptide comprising the amino acid sequence of SEQ ID NO: 2. 2. The method of claim 1 , wherein the protein induces pro-inflammatory cytokines. 3. The method of claim 2 , wherein the pro-inflammatory cytokine is a cytokine selected from the group consisting of interleukin (IL)-6, IL-1β, IL-2, IL-10, IL-22, interferon γ, and INFα. 4. A method of promoting immune activity in a patient, comprising administering a dimeric proinsulin mutant with C-peptide partially deleted to the patient in need thereof, wherein the dimeric proinsulin mutant with C-peptide partially deleted is a dimer of a peptide comprising the amino add sequence of SEQ ID NO: 2. 5. The method of claim 4 , wherein the protein induces pro-inflammatory cytokines. 6. The method of claim 5 , wherein the pro-inflammatory cytokine is a cytokine selected from the group consisting of interleukin (IL)-6, IL-1β, IL-2, IL-10, IL-22, interferon γ, and TNFα.
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- What does patent US9669073B2 cover?
- The present disclosure relates to a composition for promoting immune activity including a protein selected from the group consisting of dimeric proinsulin, C-peptide partially deleted mutant of dimeric proinsulin, and C-peptide partially deleted mutant of monomeric proinsulin as an effective component and a composition for immunosuppression including C-peptide site of proinsulin as an effective…
- Who is the assignee on this patent?
- Univ Konkuk Ind Coop Corp
- What technology area does this patent fall under?
- Primary CPC classification A61K38/28. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jun 06 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).