Small molecule inhibitors of superoxide dismutase expression

Patent metadata

Field	Value
Publication number	US-9669014-B2
Application number	US-201615083848-A
Country	US
Kind code	B2
Filing date	Mar 29, 2016
Priority date	Jan 28, 2014
Publication date	Jun 6, 2017
Grant date	Jun 6, 2017

Abstract

Disclosed are new small molecules and the uses thereof for inhibiting superoxide dismutase (SOD) expression. Also disclosed are pharmaceutical compositions comprising the small molecule inhibitors which may be administered in methods of treating diseases or disorders associated with elevated SOD expression or activity, including neurological diseases and disorders such as amyotrophic lateral sclerosis (ALS).

First claim

We claim:

1. A method for treating a disease or disorder that is associated with elevated SOD1 expression or activity in a patient in need thereof, the method comprising administering to the patient an effective amount of the following compound for reducing SOD1 expression or activity:

2. The method of claim 1 , wherein the disease or disorder is a neurological disease or disorder.

3. The method of claim 2 , wherein the neurological disease or disorder is a degenerative neurological disease or disorder.

4. The method of claim 3 , wherein the degenerative neurological disease or disorder is amyotrophic lateral sclerosis (ALS).

5. A method for treating a disease or disorder that is associated with elevated SOD1 expression or activity in a patient in need thereof, the method comprising administering to the patient an effective amount of the following compound for reducing SOD1 expression or activity:

6. The method of claim 5 , wherein the disease or disorder is a neurological disease or disorder.

7. The method of claim 6 , wherein the neurological disease or disorder is a degenerative neurological disease or disorder.

8. The method of claim 7 , wherein the degenerative neurological disease or disorder is amyotrophic lateral sclerosis (ALS).

Assignees

• Univ Northwestern

Inventors

• Siddique Teepu
• Lukas Thomas J
• Arrat Hasan
• Schiltz Gary E

Classifications

• C07D271/113

  with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical · CPC title

• A61K31/4439 Primary

  containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole (nicotine A61K31/465) · CPC title

• C07D413/14

  containing three or more hetero rings · CPC title

• C07D417/04

  directly linked by a ring-member-to-ring-member bond · CPC title

• C07D413/04

  directly linked by a ring-member-to-ring-member bond · CPC title