Method and system for non-invasively monitoring biological or biochemical parameters of individual

Patent metadata

Field	Value
Publication number	US-9668672-B2
Application number	US-201213564381-A
Country	US
Kind code	B2
Filing date	Aug 1, 2012
Priority date	Jan 28, 2011
Publication date	Jun 6, 2017
Grant date	Jun 6, 2017

Abstract

A system and method are presented for use in monitoring one or more conditions of a subject's body. The system includes a control unit which includes an input port for receiving image data, a memory utility, and a processor utility. The image data is indicative of data measured by a pixel detector array and is in the form of a sequence of speckle patterns generated by a portion of the subject's body in response to illumination thereof by coherent light according to a certain sampling time pattern. The memory utility stores one or more predetermined models, the model comprising data indicative of a relation between one or more measurable parameters and one or more conditions of the subject's body. The processor utility is configured and operable for processing the image data to determine one or more corresponding body conditions; and generating output data indicative of the corresponding body conditions.

First claim

The invention claimed is:

1. A system for use in monitoring one or more conditions of a subject's body, the system comprising a control unit being a computer system comprising:
an input port which is in data communication with an external device and is configured and operable to receive input data from said external device, said input data being indicative of defocused coherent image data in the form of a sequence of speckle patterns collected from the body with a certain sampling time pattern;
a non-transitory computer readable memory storing the received defocused image data and storing model data comprising one or more models describes a relation between one or more conditions of the subject's body and one or more parameters derivable from defocused coherent image data;
a processor configured and operable to access and process the defocused coherent image data to translate said defocused coherent image data into said one or more body conditions, said translating of the defocused coherent image data into said one or more body conditions comprising:
for each two successive speckle patterns in said sequence stored in the memory, calculating a spatial correlation function having a correlation peak, and obtaining a sequence of spatial correlation functions, and
transforming the sequence of the spatial correlation functions into a time varying spatial correlation function corresponding to temporal variations spatial features of the correlation peak during a sampling period being indicative of a change of the speckle pattern over time, which is indicative of a motion in the subject's body during collection of the defocused coherent image, said spatial features comprising at least a spatial position of the correlation peak, a value of the correlation peak, and a size of the correlation peak, each of the spatial features corresponding to a model parameter derived from the defocused coherent image data;
applying model based processing to the time-varying spatial correlation function using at least one selected model stored in the memory, by selecting at least one of the spatial features of the time-varying spatial correlation function to determine the at least one model parameter, and determining said one or more body conditions from the model data; and
generating output data indicative of said determined one or more conditions of the subject's body; and

an output port configured to transmit said output data to at least one device configured to present the output data to a user, the output data comprising at least one of a graph of the time varying spatial correlation function and a value of at least one body condition being determined.

2. The system of claim 1 , wherein the at least one selected spatial feature of the time-varying spatial correlation function comprises at least one of the following: a spatial position of the correlation peak, and the value of the correlation peak.

3. The system of claim 1 , wherein said one or more body conditions to be monitored comprises blood glucose concentration.

4. The system of claim 3 , wherein the at least one selected spatial feature of the time varying spatial correlation function comprises at least one of the following: positive amplitude of the correlation peak, and a ratio between positive and negative amplitudes of the correlation peak.

5. The system of claim 1 , wherein said one or more body conditions to be monitored comprises blood alcohol concentration.

6. The system of claim 5 , wherein the at least one parameter of the time varying function comprises at least one of the following: pulse size, positive pulse size, distance between peak polarities, ratio between main and secondary peak positions, ratio between main and secondary peak amplitudes, and standard deviation of background noise.

7. The system of claim 1 , wherein said one or more body conditions to be monitored comprise intra ocular pressure (IOP).

8. The system of claim 7 , wherein the at least one parameter of the time varying function comprises an amplitude of oscillation.

9. The system of claim 1 , wherein the body condition is blood pulse pressure.

10. The system of claim 8 , wherein the at least one parameter of the time varying spatial correlation function comprises the amplitude of the main peak.

11. The system of claim 1 , wherein the body condition is dehydration.

12. The system of claim 1 , wherein the body condition is coagulation of blood.

13. The system of claim 1 , wherein the subject is a ruminant.

14. The system of claim 1 , wherein the body condition is temperature.

15. The system of claim 1 , wherein the body condition is flow velocity and volume.

16. The system of claim 1 , wherein the external device comprises:
an imaging device comprising a coherent light source configured for illuminating a portion of the subject's body with defocused illumination of a predetermined number of wavelengths according to the sampling time pattern during a sampling period, and a pixel detector array configured and operable for detecting the successive speckle patterns generated by the illuminated portion of the body during the sampling period and generating said image data indicative of the sequence of the speckle patterns to be received by said input port of the control unit.

17. The system of claim 1 , wherein said one or more conditions of a subject's body are associated with one or more properties of at least one bodily fluid.

18. The system of claim 17 , wherein said at least one bodily fluid comprises at least one of blood and aqueous humor.

Assignees

• Zalevsky Zeev
• Garcia Javier
• Mico Vincente
• Belkin Michael
• Biederman Yevgeny
• Margalit Israel
• Univ Bar Ilan
• Univ Valencia

Inventors

• Zalevsky Zeev
• Garcia Javier
• Mico Vincente
• Belkin Michael
• Biederman Yevgeny
• Margalit Israel

Classifications

• A61B5/0205

  Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition · CPC title

• A61B5/0295

  using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography · CPC title

• A61B5/0803 Primary

  Recording apparatus specially adapted therefor · CPC title

• A61B5/02133

  by using induced vibration of the blood vessel · CPC title

• A61B5/01

  Measuring temperature of body parts {; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue} (clinical contact thermometers G01K13/20) · CPC title