Polymer-nanostructure composition for selective molecular recognition

Patent metadata

Field	Value
Publication number	US-9664677-B2
Application number	US-201113090199-A
Country	US
Kind code	B2
Filing date	Apr 19, 2011
Priority date	Apr 19, 2010
Publication date	May 30, 2017
Grant date	May 30, 2017

Abstract

A composition can include a complex, where the complex includes a photoluminescent nanostructure and a polymer free from selective binding to an analyte, the polymer adsorbed on the photoluminescent nanostructure, and a selective binding site associated with the complex.

First claim

What is claimed is:

1. A composition, comprising:
a complex, wherein the complex includes:
a nanostructure, wherein the nanostructure is a photoluminescent nanostructure,
wherein the photoluminescent nanostructure is a single-walled carbon nanotube; and

a polymer, the polymer adsorbed on the nanostructure and the polymer being free from selective binding to an analyte in the absence of being adsorbed on the nanostructure,
wherein the polymer is a boronic acid functionalized phenoxy dextran; and

a selective binding site for the analyte on the complex.

2. The composition of claim 1 , wherein the analyte is a monosaccharide, a polysaccharide, an amino acid, a nucleotide, an oligonucleotide, a lipid, a polylipid, a steroid, a peptide, a protein, riboflavin, or nitric oxide.

3. The composition of claim 1 , wherein the analyte is 17-α-estradiol, 2,4-dinitrophenol, acetylcholine chloride, α-tocopherol, adenosine, adenosine-5′-triphosphate, cyclic adenosine monophosphate, creatinine, cytidine, D-aspartic acid, D-fructose, D-galactose, D-glucose, D-mannose, dopamine, glycine, guanosine, histamine, L-ascorbic acid, L-citrulline, L-histidine, L-thyroxine, melatonin, NADH, quinine, salicylic acid, serotonin, sodium azide, sodium pyruvate, sucrose, thymidine, tryptophan, tyramin or urea.

4. The composition of claim 1 , further comprising an amount of the analyte.

5. The composition of claim 4 , wherein the analyte is a therapeutic.

6. A system comprising:
the composition of claim 1 ;
an electromagnetic radiation source having an excitation wavelength directed at the composition; and
a detector configured to receive an emission wavelength from the composition.

Assignees

• Strano Michael S
• Zhang Jingqing
• Barone Paul Walter
• Heller Daniel A
• Kim Jong-Ho
• Massachusetts Inst Technology

Inventors

• Strano Michael S
• Zhang Jingqing
• Barone Paul Walter
• Heller Daniel A
• Kim Jong-Ho

Classifications

• G01N33/542 Primary

  with steric inhibition or signal modification, e.g. fluorescent quenching · CPC title

• B82Y30/00

  Nanotechnology for materials or surface science, e.g. nanocomposites · CPC title