Tunable optofluidic apparatus, method, and applications

Patent metadata

Field	Value
Publication number	US-9664500-B2
Application number	US-201314383544-A
Country	US
Kind code	B2
Filing date	Mar 7, 2013
Priority date	Mar 8, 2012
Publication date	May 30, 2017
Grant date	May 30, 2017

Abstract

Embodiments include optofluidic apparatus that may be used to detect and manipulate nanoparticles or biomolecules within a fluid. To achieve that result, the embodiments use a fluidic channel located over a substrate. Particular embodiments also use: (1) an optical waveguide located over the substrate and particularly within the fluidic channel along with an optical resonator that may or may not be located within fluidic channel; and also (2) a phase shifter component coupled to either the waveguide or the optical resonator. Additional embodiments use an MZI or an MZI with an optical resonator to further provide the phase shifter component coupled to one arm of the MZI or the optical resonator.

First claim

We claim:

1. An optofluidic apparatus comprising:
only a single fluidic channel located over a substrate;
a Mach-Zehnder interferometer located over the substrate and not within the single fluidic channel, at least one output of the Mach-Zehnder interferometer being located within the single fluidic channel; and
a phase shifter component located outside of the single fluidic channel and coupled with one arm of the Mach-Zehnder interferometer.

2. The optofluidic apparatus of claim 1 further comprising:
a light source coupled with an input of the Mach-Zehnder interferometer; and
a photodetector coupled with an output of the Mach-Zehnder interferometer.

3. The optofluidic apparatus of claim 2 wherein the light source is in the visible range.

4. The optofluidic apparatus of claim 2 wherein the light source is in the ultraviolet range.

5. The optofluidic apparatus of claim 1 wherein the phase shifter component comprises an electric microheater.

6. The optofluidic apparatus of claim 1 wherein the phase shifter component comprises a p-i-n diode.

7. A method for operating an optofluidic apparatus comprising:
providing an optofluidic apparatus including:
only a single fluidic channel located over a substrate and including a fluid further including at least one analyte; and
a waveguide based Mach-Zehnder interferometer also located over the substrate;
where at least an output portion of the waveguide based Mach-Zehnder interferometer is located at least in-part within the fluidic channel; and

a phase shifter component also located over the substrate but not in the fluidic channel, and operatively coupled with the waveguide based Mach-Zehnder interferometer;

introducing a light beam into one end of the waveguide based Mach-Zehnder interferometer; and
actuating the phase shifter component to detect and manipulate the at least one analyte within the fluid.

8. The method of claim 7 wherein the at least one analyte comprises at least one of a nanoparticle and a biomolecule.

9. The method of claim 7 wherein the at least one analyte is detected and manipulated without changing a temperature of the fluid.

Assignees

• Univ Cornell

Inventors

• Wang Michelle D
• Lipson Michal
• Soltani Mohammad

Classifications

• G01N2021/7779

  interferometric · CPC title

• G02B6/10

  of the optical waveguide type (G02B6/02, G02B6/24 take precedence; devices or arrangements for the control of light by electric, magnetic, electro-magnetic or acoustic means G02F1/00; transferring the modulation of modulated light G02F2/00; optical logic elements G02F3/00; optical analogue/digital converters G02F7/00) · CPC title

• G01N21/7746

  the waveguide coupled to a cavity resonator · CPC title

• G01N21/7703 Primary

  using reagent-clad optical fibres or optical waveguides (using measurement of total internal reflection or attenuated total reflection G01N21/552; optical fibres or waveguides per se G02B) · CPC title

• G01B9/02001

  characterised by controlling or generating intrinsic radiation properties · CPC title