Hybridization linkers
US-9222082-B2 · Dec 29, 2015 · US
Mutated immunoglobulin-binding polypeptides
US9663558B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9663558-B2 |
| Application number | US-201414904077-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 10, 2014 |
| Priority date | Jul 10, 2013 |
| Publication date | May 30, 2017 |
| Grant date | May 30, 2017 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
A polypeptide with improved alkaline stability, which polypeptide comprises a mutant of a B or C domain of Staphylococcus Protein A, as specified by SEQ ID NO 1 or SEQ ID NO 2, or of Protein Z, as specified by SEQ ID NO 3, wherein at least the glutamine residue at position 15 has been mutated to an amino acid other than asparagine. The invention also discloses multimers of the polypeptide, as well as separation matrices comprising the multimers or polypeptides.
First claim
Opening claim text (preview).
What is claimed is: 1. A polypeptide with improved alkaline stability, wherein the polypeptide comprises the amino acid sequence of SEQ ID NOS: 6-10, 12, and 13. 2. The polypeptide according to claim 1 , comprising the amino acid sequence selected from the group consisting of SEQ ID NO 6, SEQ ID NO 8, SEQ ID NO 9, SEQ ID NO 10 and SEQ ID NO 13. 3. A multimer comprising a plurality of polypeptide units as defined by claim 1 . 4. The polypeptide according to claim 1 , wherein the polypeptide is the amino acid sequence of SEQ ID NO: 6. 5. The polypeptide according to claim 1 , wherein the polypeptide is the amino acid sequence of SEQ ID NO: 7. 6. The polypeptide according to claim 1 , wherein the polypeptide is the amino acid sequence of SEQ ID NO: 8. 7. The polypeptide according to claim 1 , wherein the polypeptide is the amino acid sequence of SEQ ID NO: 9. 8. The polypeptide according to claim 1 , wherein the polypeptide is the amino acid sequence of SEQ ID NO: 10. 9. The polypeptide according to claim 1 , wherein the polypeptide is the amino acid sequence of SEQ ID NO: 12. 10. The polypeptide according to claim 1 , wherein the polypeptide is the amino acid sequence of SEQ ID NO: 13. 11. A multimer comprising a plurality of polypeptide units as defined by claim 4 . 12. A multimer comprising a plurality of polypeptide units as defined by claim 5 . 13. A multimer comprising a plurality of polypeptide units as defined by claim 6 . 14. A multimer comprising a plurality of polypeptide units as defined by claim 7 . 15. A multimer comprising a plurality of polypeptide units as defined by claim 8 . 16. A multimer comprising a plurality of polypeptide units as defined by claim 9 . 17. A multimer comprising a plurality of polypeptide units as defined by claim 10 .
Assignees
Inventors
Classifications
- C07K14/31Primary
from Staphylococcus (G) · CPC title
consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds · CPC title
Affinity chromatography or related techniques based upon selective absorption processes · CPC title
Inorganic carriers, supports or substrates · CPC title
Phases chemically bonded to a substrate, e.g. to silica or to polymers · CPC title
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- What does patent US9663558B2 cover?
- A polypeptide with improved alkaline stability, which polypeptide comprises a mutant of a B or C domain of Staphylococcus Protein A, as specified by SEQ ID NO 1 or SEQ ID NO 2, or of Protein Z, as specified by SEQ ID NO 3, wherein at least the glutamine residue at position 15 has been mutated to an amino acid other than asparagine. The invention also discloses multimers of the polypeptide, as…
- Who is the assignee on this patent?
- Ge Healthcare Bio Sciences Ab
- What technology area does this patent fall under?
- Primary CPC classification C07K14/31. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 30 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).