3-aryl propiolonitrile compounds for thiol labeling

Patent metadata

Field	Value
Publication number	US-9663454-B2
Application number	US-201414899883-A
Country	US
Kind code	B2
Filing date	Jul 4, 2014
Priority date	Jul 4, 2013
Publication date	May 30, 2017
Grant date	May 30, 2017

Abstract

The present invention relates to a process for labeling compounds comprising thiol moieties with 3-arylpropiolonitrile compounds, to 3-arylpropiolonitrile compounds substituted with tag moieties and to specific 3-arylpropiolonitrile linkers.

First claim

The invention claimed is:

1. A compound of formula (III):

wherein
each of R 1 , R 2 , R 4 , and R 5 is a hydrogen atom;
R 3 is a fluorescent probe or a drug, which is bounded to the phenyl ring via a linker; and
R 6 is such that R 6 —SH is a protein containing a thiol moiety.

Assignees

• Univ Strasbourg
• Centre Nat Rech Scient

Inventors

• Wagner Alain
• Koniev Oleksandr

Classifications

• C07C335/22

  being further substituted by carboxyl groups · CPC title

• C07D337/04

  not condensed with other rings · CPC title

• C07C309/42

  having the sulfo groups bound to carbon atoms of non-condensed six-membered aromatic rings · CPC title

• C07C2602/24

  the ring system containing nine carbon atoms, e.g. perhydroindane · CPC title

• C07D249/06

  with aryl radicals directly attached to ring atoms · CPC title