Method of sorting particles or particle clusters in a fluid flowing in a channel

Patent metadata

Field	Value
Publication number	US-9662602-B2
Application number	US-43799209-A
Country	US
Kind code	B2
Filing date	May 8, 2009
Priority date	May 13, 2008
Publication date	May 30, 2017
Grant date	May 30, 2017

Abstract

The invention relates to a method of sorting submillimetric particles entrained in a fluid flowing in an axial direction of a main channel, the particles being of density different from the density of the fluid, and the method being characterized in that it implements, in a first region of the main channel, focusing of the particles along a wall ( 7 ) of the main channel ( 1 ) by means of at least one focusing device ( 3 ), and downstream from said region, collecting of particles in at least one sorting and take-off device ( 40 ) in communication with the main channel ( 1 ) via an opening such that the particles collected are selected by the take-off device as a function of the size of said particles, and in that said at least one sorting and take-off device is a recirculation chamber ( 40 ) in communication with the main channel ( 1 ) and presenting at least one recirculation zone ( 41 ) for concentrating the collected particles.

First claim

The invention claimed is:

1. A method of size sorting submillimetric particles or submillimetric particle clusters entrained in a fluid flowing in an axial direction of a main channel, the particles being of density different from the density of the fluid, the method being characterized in that it implements:
in a first region of the main channel, focusing particle by means of at least one focusing device,
said at least one focusing device presenting at least one lateral channel for fluid injection that opens in a wall of the main channel,
such that the focused particles or particle clusters are distributed on flow lines having a position along said wall that depends on their sizes,

and downstream from said region, in a second region of the main channel, collecting said focused particles or particle clusters
in at least one sorting and take-off device in communication with the main channel via an opening that is provided in said wall,
said opening having a dimension that is configured to allow selection of particles or particle clusters as a function of their line of flow,
so that the collected particles or particle clusters are selected by the sorting and take-off device as a function of the size of said particles or particle clusters,

and in that said at least one sorting and take-off device is a recirculation chamber in communication with the main channel and presenting at least one recirculation zone for concentrating the collected particles.

2. A method according to claim 1 , characterized in that said recirculation chamber further comprises sequential take-off means.

3. A method according to claim 1 , characterized in that said first region is of substantially constant section, and in that said particle focusing is performed by injecting into the main channel a fluid from said focusing device, which presents at least one lateral channel at an angle of incidence α of not less than 5° and preferably of substantially equal to 90° to focus the particles on said wall of said main channel downstream from the region where the lateral injection is performed.

4. A method according to claim 1 , characterized in that it implements, opposite from the injection region and facing and/or downstream therefrom, take off by means of at least one take-off channel.

5. A method according to claim 4 , characterized in that the size of the take-off channel(s) is less than the size of the finest particles flowing in the main channel.

6. A method according to claim 1 , characterized in that the mean speed in the main channel lies in the range 1 mm/s to 50 mm/s, and in that the speed in a recirculation zone lies in the range 5 μn/s to 1000 μm/s.

7. A method according to claim 1 , characterized in that said at least one recirculation chamber is coupled to a leakage pumping channel.

8. A method according to claim 7 , characterized in that the leakage flow in the leakage pumping channel takes place continuously at an adjustable rate in such a manner as to enable the size of the particles to be selected.

9. A method according to claim 8 , characterized in that the flow rate in a leakage pumping channel lies in the range 0.1 μL/h to 500 μL/h.

10. A method according to claim 1 , characterized in that it presents a plurality of said sorting and take-off devices in cascade arranged in such a manner as to collect particles of increasing sizes.

11. A method according to claim 10 , characterized in that at least one additional focusing device is placed between two of said sorting and take-off devices in cascade.

12. A method according to claim 1 , characterized in that it includes at least one row of pillars, the row being inclined relative to the axis of the main channel and extending between said wall of the main channel along which said focusing takes place and the opposite wall to deflect particles of diameter greater than a given diameter Dc, and in that it includes a recirculation chamber opening out into said opposite wall of the main channel in the vicinity of and upstream from the row of pillars.

13. A method according to claim 12 , characterized in that a said row of pillars is disposed downstream from said at least one focusing device and between the focusing device and said recirculation chamber.

14. A method according to claim 12 , characterized in that the row of pillars is disposed between two of said recirculation chambers.

15. A method according to claim 1 , characterized in that it includes an enlarged region of the main channel constituting said recirculation chamber.

16. A method according to claim 15 , characterized in that the enlarged region of the main channel includes at least one upstream wall substantially perpendicular to the flow axis of the fluid in the main channel.

17. A method according to claim 1 , characterized in that said at least one recirculation chamber is of pseudo-rectangular, circular, or polygonal shape, this recirculation chamber being in communication with the main channel via an opening.

18. A device for sorting particles entrained in a fluid flowing in an axial direction of a main channel, the device being characterized in that
the main channel presents
a first region presenting at least one focusing device, and
a second region situated downstream from said first region and presenting at least one take-off device,

said at least one focusing device
presenting at least one lateral channel for fluid injection that opens in a wall of the main channel,
for focusing the particles along the wall of the main channel such that the focused particles are distributed on flow lines having a position along said wall that depends on their size,

said at least one take-off device
forming a recirculation chamber in communication with an opening that is provided in said wall of the main channel and
presenting at least one recirculation zone for concentrating the collected particles,
wherein said opening has a dimension that is configured to allow selection of the particles as a function of their flow line.

Assignees

• Le Vot Sophie
• Berthier Jean
• Rivera Florence
• Commissariat Energie Atomique

Inventors

• Le Vot Sophie
• Berthier Jean
• Rivera Florence

Classifications

• G01N2015/0288

  Sorting the particles · CPC title

• B01L3/502761

  specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules · CPC title

• B01L2300/0816

  Cards, e.g. flat sample carriers usually with flow in two horizontal directions · CPC title

• B01L2200/0647

  Handling flowable solids, e.g. microscopic beads, cells, particles · CPC title

• B01L2200/0652

  Sorting or classification of particles or molecules · CPC title