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Compositions and methods for the treatment of systemic inflammatory response syndromes
US9657109B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9657109-B2 |
| Application number | US-201213667346-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 2, 2012 |
| Priority date | Nov 2, 2012 |
| Publication date | May 23, 2017 |
| Grant date | May 23, 2017 |
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Abstract
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Described herein are peptides from secretory phospholipase A 2 -IB and antibodies that can be used to reduce the contribution of the gastrointestinal tract to inflammatory processes including systemic inflammatory responses. Specifically, antibodies that bind specifically a peptide from secretory phospholipase A 2 -IB prevent death in a mouse model of LPS-induced endotoxemia. The antibodies described herein are particularly useful to treat systemic inflammatory response syndromes, including sepsis.
First claim
Opening claim text (preview).
The invention claimed is: 1. A feed or a food composition comprising an isolated antibody that specifically binds secretory phospholipase A 2 -IB, wherein the isolated antibody specifically binds a peptide (V/A/R)PYNK(A/E)(H/Y)K (SEQ ID NO. 6). 2. The feed or a food composition of claim 1 , wherein the peptide comprises 8 to 38 contiguous amino acids of the secretory phospholipase A 2 -IB. 3. The feed or a food composition of claim 1 , wherein the peptide comprises a sequence selected from VPYNKEYK (SEQ ID NO. 1), APYNKAHK(SEQ ID NO. 2), APYNKEHK (SEQ ID NO. 3), RPYNKEYK (SQ ID NO. 4), and VPYNKEHK (SEQ ID NO. 5). 4. The feed or a food composition of claim 1 , wherein the isolated antibody is a polyclonal antibody, a monoclonal antibody, a humanized antibody, or an avian egg yolk antibody. 5. The feed or a food composition of claim 1 , in the form of a human food composition. 6. The feed or a food composition of claim 1 , in the form of an animal feed composition. 7. The feed or a food composition of claim 1 , wherein the antibody is an avian egg yolk antibody. 8. An oral, solid pharmaceutical composition comprising a pharmaceutically acceptable excipient and isolated antibody that specifically binds secretory phospholipase A 2 -IB, wherein the isolated antibody specifically binds a peptide (V/A/R)PYNK(A/E)(H/Y)K (SEQ ID NO. 6). 9. The oral, solid pharmaceutical dosage form of claim 8 , wherein the isolated antibody is a polyclonal antibody, a monoclonal antibody, a humanized antibody, or an avian egg yolk antibody. 10. The oral, solid pharmaceutical dosage form of claim 8 , wherein the isolated antibody is an avian egg yolk antibody.
Assignees
Inventors
Classifications
Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title
comprising antibodies · CPC title
isolated from eggs · CPC title
from birds · CPC title
Phospholipase A2 (3.1.1.4) · CPC title
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- What does patent US9657109B2 cover?
- Described herein are peptides from secretory phospholipase A 2 -IB and antibodies that can be used to reduce the contribution of the gastrointestinal tract to inflammatory processes including systemic inflammatory responses. Specifically, antibodies that bind specifically a peptide from secretory phospholipase A 2 -IB prevent death in a mouse model of LPS-induced endotoxemia. The antibodies des…
- Who is the assignee on this patent?
- Wisconsin Alumni Res Found
- What technology area does this patent fall under?
- Primary CPC classification C07K16/40. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 23 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).