Methods and compositions for cell-proliferation-related disorders
US-2015240286-A1 · Aug 27, 2015 · US
Therapeutically active compounds and their methods of use
US9656999B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9656999-B2 |
| Application number | US-201615337683-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 28, 2016 |
| Priority date | Jan 6, 2012 |
| Publication date | May 23, 2017 |
| Grant date | May 23, 2017 |
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- Title
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Abstract
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Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.
First claim
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The invention claimed is: 1. A method of synthesizing comprising reacting 1-[4-chloro-6-(6-trifluoromethylpyridin-2-yl)-[1,3,5]triazin-2-ylamino]-2-methylpropan-2-ol with 2-trifluoromethylpyridin-4-ylamine in the presence of sodium tert-butoxide and Pd(dppf)Cl 2 . 2. The method of claim 1 , wherein the 1-[4-chloro-6-(6-trifluoromethylpyridin-2-yl)-[1,3,5]triazin-2-ylamino]-2-methylpropan-2-ol is synthesized by a method comprising reacting 2,4-dichloro-6-(6-trifluoromethylpyridin-2-yl)-1,3,5-triazine with 2-hydroxy-2-methyl-1-propylamine. 3. The method of claim 2 , wherein the 2,4-dichloro-6-(6-trifluoromethylpyridin-2-yl)-1,3,5-triazine is synthesized by a method comprising reacting 6-(6-trifluoromethylpyridin-2-yl)-1H-1,3,5-triazine-2,4-dione with POCl 3 and PCl 5 . 4. The method of claim 3 , wherein the 6-(6-trifluoromethylpyridin-2-yl)-1H-1,3,5-triazine-2,4-dione is synthesized by a method comprising reacting 6-trifluoromethylpyridine-2-carboxylic acid methyl ester with biuret in the presence of Na in ethanol.
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Classifications
specific for leukemia · CPC title
having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine (melarsoprol A61K31/555 {; with four nitrogen atoms A61K31/495}) · CPC title
linked by a chain containing hetero atoms as chain links · CPC title
with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines · CPC title
Bridged systems · CPC title
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- What does patent US9656999B2 cover?
- Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.
- Who is the assignee on this patent?
- Agios Pharmaceuticals Inc
- What technology area does this patent fall under?
- Primary CPC classification C07D413/14. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 23 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 4 related publications on this page (citations in our corpus or others sharing the same primary CPC).