Compound, optical resolution method, and derivative of an optical isomer of an amino acid

Patent metadata

Field	Value
Publication number	US-9656948-B2
Application number	US-201514918743-A
Country	US
Kind code	B2
Filing date	Oct 21, 2015
Priority date	Sep 2, 2013
Publication date	May 23, 2017
Grant date	May 23, 2017

Abstract

Disclosed is a compound represented by chemical formula (1):

or chemical formula (2):

First claim

What is claimed is:

1. An optical resolution method, comprising:
reacting a mixture of optically active amino acids with a compound represented by chemical formula (1):

or chemical formula (2):

to obtain a derivatized amino acid mixture; and
subjecting the derivatized amino acid mixture to column chromatography to separate respective optical isomers of the derivatized amino acid mixture.

2. The optical resolution method as claimed in claim 1 , wherein the mixture of optically active amino acids is reacted with the compound at room temperature.

3. The optical resolution method as claimed in claim 2 , wherein the mixture of optically active amino acids is reacted with the compound for a duration of from one to ten minutes.

4. The optical resolution method as claimed in claim 1 , further comprising stopping the reaction between the mixture of optically active amino acids and the compound by adding an aqueous acid solution.

5. The optical resolution method as claimed in claim 4 , wherein the aqueous acid solution is an aqueous trifluoroacetic acid solution.

Assignees

• Shiseido Co Ltd
• Univ Kyushu Nat Univ Corp

Inventors

• Mita Masashi
• Hamase Kenji
• Oyama Tsubasa

Classifications

• C07C227/36 Primary

  Racemisation of optical isomers · CPC title

• C07C227/34

  by separation of optical isomers · CPC title

• C07D215/22 Primary

  attached in position 2 or 4 · CPC title

• C07D401/12

  linked by a chain containing hetero atoms as chain links · CPC title

• C07C229/08

  the nitrogen atom of the amino group being further bound to hydrogen atoms · CPC title