Composition comprising a purified extract isolated from Pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient or the compounds isolated therefrom, as an active ingredient for treating a chronic obstructive pulmonary disease and the use thereof

Patent metadata

Field	Value
Publication number	US-9655871-B2
Application number	US-201414780503-A
Country	US
Kind code	B2
Filing date	Apr 9, 2014
Priority date	Apr 10, 2013
Publication date	May 23, 2017
Grant date	May 23, 2017

Abstract

A composition comprising a purified extract isolated from Pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient or the compounds isolated therefrom as an active ingredient for treating a chronic obstructive pulmonary disease and the use thereof. Inventive purified extract and compounds showed potent anti-COPD activity without beta-2-receptor agonistic response through various in vivo tests as well as in vitro test. Therefore, it can be used as the therapeutics or functional health food for treating and preventing chronic obstructive pulmonary disease (COPD).

First claim

The invention claimed is:

1. A method of treating chronic obstructive pulmonary disease (COPD) in mammals, wherein the method comprises administering a therapeutically effective amount of the purified extract with the secondary fractionation (ATC2) containing 30-60% (w/w) verproside, 0.5-10% (w/w) veratric acid, 2-20% (w/w) catalposide, 1- 10% (w/w) picroside II, 1-10% (w/w) isovanilloyl catalpol and 2-20% (w/w) 6-O-veratroyl catalpol based on the weight of total extract (100%) of Pseudolysimachion rotundum var subintegrum into the mammal suffering from chronic obstructive pulmonary disease (COPD).

2. A method of treating chronic obstructive pulmonary disease (COPD) in mammals, wherein the method comprises administering a composition comprising therapeutically effective amount of the purified extract with the secondary fractionation (ATC2) containing 30-60% (w/w) verproside, 0.5-10% (w/w) veratric acid, 2-20% (w/w) catalposide, 1-10% (w/w) picroside II, 1-10% (w/w) isovanilloyl catalpol and 2-20% (w/w) 6-O-veratroyl catalpol based on the weight of total extract (100%) of Pseudolysimachion rotundum var subintegrum and the pharmaceutically acceptable carriers or excipients, into the mammal suffering from chronic obstructive pulmonary disease (COPD).

3. A method of treating chronic obstructive pulmonary disease (COPD) in mammals, wherein the method comprises administering a therapeutically effective amount of the combined compounds contained in Pseudolysimachion rotundum var subintegrum with mixed weight ratio of 45%-90% verproside, 1.0%-7.0% veratric acid, 3.0%-15% catalposide, 2.0%-10% picroside II, 2.0%-10% isovanilloyl catalpol and 2.0-15% 6-O-veratroyl catalpol into the mammal suffering from chronic obstructive pulmonary disease (COPD).

4. A method of treating chronic obstructive pulmonary disease (COPD) in mammals, wherein the method comprises administering a composition comprising a therapeutically effective amount of the combined compounds contained in Pseudolysimachion rotundum var subintegrum with mixed weight ratio of 45%-90% verproside, 1.0%-7.0% veratric acid, 3.0%-15% catalposide, 2.0%-10% picroside II, 2.0%-10% isovanilloyl catalpol and 2.0-15% 6-O-veratroyl catalpol, and the pharmaceutically acceptable carriers or excipients, into the mammal suffering from chronic obstructive pulmonary disease (COPD).

Assignees

• Yungjin Pharmaceutical Co Ltd
• Korea Res Inst Bioscience & Biotechnology
• Yungjin Pharmaceutical Co Ltd

Inventors

• Lee Yongnam
• Yoo Ji-Seok
• Shin Dae-Hee
• Ryoo Byung-Hwan
• Ahn Kyung Seop
• Oh Sei Ryang
• Lee Hyeong Kyu
• Shin In Sik
• Kim Doo Young
• Kwon Ok-Kyoung
• Song Hyuk Hwan
• Kim Seung Hyung
• Lee Suui

Classifications

• A61P11/00

  Drugs for disorders of the respiratory system · CPC title

• A61K31/7048

  having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin {, digitoxin or digoxin} · CPC title

• A61K2236/00

  Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine · CPC title

• A61K31/194

  having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid · CPC title

• A23L33/105

  Plant extracts, their artificial duplicates or their derivatives · CPC title