Kits including implantable medical devices and antioxidants

Patent metadata

Field	Value
Publication number	US-9655751-B2
Application number	US-201313759898-A
Country	US
Kind code	B2
Filing date	Feb 5, 2013
Priority date	Jul 25, 2005
Publication date	May 23, 2017
Grant date	May 23, 2017

Abstract

Methods of incorporating an antioxidant into a medical device including a polymer are described, and methods of packaging medical devices.

First claim

What is claimed is:

1. A kit comprising:
an implantable medical device comprising a polymer and optionally comprising a device antioxidant;
a primary package with an interior, an interior surface and an exterior surface, the primary package comprising a second antioxidant, which may be the same as or different from the device antioxidant; and
a secondary package with an interior and an interior surface, the secondary package being impermeable or substantially impermeable to the second antioxidant;
wherein the implantable medical device is sealed inside the primary package, and a fluid filling the interior of the primary package comprises at least 0.001 μg/cm 3 of the second antioxidant;
wherein the primary package is sealed within the secondary package; and
wherein the primary package is permeable to the second antioxidant.

2. The kit of claim 1 , wherein a carrier comprising the second antioxidant is sealed within the primary package, the primary package interior surface is at least partially coated with a material comprising the second antioxidant, the second antioxidant is integrated with the primary package, or a combination thereof.

3. The kit of claim 1 , wherein a carrier comprising the second antioxidant is sealed within the primary package, a carrier comprising the second antioxidant is sealed within the secondary package, the primary package exterior surface is at least partially coated with a material comprising the second antioxidant, the secondary package interior surface is at least partially coated with a material comprising the second antioxidant, the second antioxidant is integrated into the primary package, the second antioxidant is integrated into the secondary package, or any combination thereof.

4. The kit of claim 1 , wherein the implantable medical device is a stent.

5. The kit of claim 4 , wherein the stent is a bioabsorbable stent.

6. The kit of claim 3 , wherein a carrier comprising the second antioxidant is sealed within the primary package, a carrier comprising the second antioxidant is sealed within the secondary package, or a combination thereof.

7. The kit of claim 3 , wherein the primary package exterior surface is at least partially coated with a material comprising the second antioxidant, the secondary package interior surface is at least partially coated with a material comprising the second antioxidant, or a combination thereof.

8. The kit of claim 3 , wherein the second antioxidant is integrated into the primary package, the second antioxidant is integrated into the secondary package, or a combination thereof.

9. The kit of claim 1 , wherein the second antioxidant is solid and is placed inside the secondary package.

10. The kit of claim 1 , wherein the fluid filling the primary package is an inert gas.

11. The kit of claim 10 , wherein the inert gas is argon, nitrogen, helium, or a combination thereof.

12. The kit of claim 1 , wherein the second antioxidant is butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA), or a combination thereof.

13. The kit of claim 3 , wherein the second antioxidant is butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA), or a combination thereof.

14. The kit of claim 6 , wherein the second antioxidant is butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA), or a combination thereof.

15. The kit of claim 7 , wherein the second antioxidant is butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA), or a combination thereof.

16. The kit of claim 8 , wherein the second antioxidant is butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA), or a combination thereof.

17. The kit of claim 9 , wherein the second antioxidant is butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA), or a combination thereof.

Assignees

• Abbott Cardiovascular Systems Inc

Inventors

• Ding Ni

Classifications

• A61L31/10 Primary

  Macromolecular materials · CPC title

• B65B55/00

  Preserving, protecting or purifying packages or package contents in association with packaging (by packaging under special atmospheric or gaseous conditions B65B31/00; devices for placing protecting sheets, plugs, or wads over contents B65B61/22) · CPC title

• B65D3/00

  Rigid or semi-rigid containers having bodies or peripheral walls of curved or partially-curved cross-section made by winding or bending paper without folding along defined lines · CPC title

• A61L31/143

  Stabilizers · CPC title

• B65D77/04

  Articles or materials enclosed in two or more containers disposed one within another · CPC title