Subject information acquisition apparatus

Patent metadata

Field	Value
Publication number	US-9655589-B2
Application number	US-201214110125-A
Country	US
Kind code	B2
Filing date	Apr 5, 2012
Priority date	Apr 8, 2011
Publication date	May 23, 2017
Grant date	May 23, 2017

Abstract

Viscoelastic characteristics in a subject are imaged by a simple method.
A viscoelasticity measurement reference layer whose elastic modulus and viscosity coefficient are known is included between an ultrasonic wave transmitting/receiving probe and the subject and distributions of elastic modulus and viscosity coefficient inside the subject are calculated from a change over time of strain generated in the viscoelasticity measurement reference layer and the subject according to a pressure applied to the subject which changes over time and known elastic modulus and viscosity coefficient of the viscoelasticity measurement reference layer.

First claim

The invention claimed is:

1. A subject information acquisition apparatus for transmitting an elastic wave to a subject, receiving the elastic wave reflected from inside the subject, and acquiring information inside the subject, the subject information acquisition apparatus comprising:
a conversion device configured to receive the elastic wave and convert the elastic wave into an electrical signal;
a reference layer which is provided between the conversion device and the subject and whose viscosity coefficient and elastic modulus are known;
a measuring unit configured to measure strain of the subject and strain of the reference layer which are generated when a pressure is applied to the subject and the reference layer by using the electrical signal; and
a calculation unit configured to calculate a viscosity coefficient (η) of the subject by using a viscosity coefficient and an elastic modulus of the reference layer, the strain of the subject, and the strain of the reference layer,
wherein
a pressure applied to the subject and the reference layer is periodic pressure application including releasing the pressure, and
the calculation unit calculates the viscosity coefficient (η) of the subject by using an area of a hysteresis loop drawn with strain values of the subject and strain values of the reference layer which are generated by the periodic pressure.

2. The subject information acquisition apparatus according to claim 1 , further comprising a control unit configured to display on a display unit a cross-sectional image of inside of the subject based on the electric signals and an image related to viscosity of the subject.

3. The subject information acquisition apparatus according to claim 2 , wherein the control unit displays on the display unit, the cross-sectional image and the image related to viscosity of the subject in parallel, switching, or an overlaid manner.

4. The subject information acquisition apparatus according to claim 1 , wherein in a case the periodic pressure application is repeatedly performed, the calculation unit calculates an area of the hysteresis loop for each period, and averages the calculated areas.

5. The subject information acquisition apparatus according to claim 4 , wherein
the pressure applied to the subject and the reference layer is instantaneously increased to a certain pressure and thereafter the certain pressure is held for a certain time period, and
the calculation unit calculates the viscosity coefficient (η) of the subject by using a strain value of the subject and a strain value of the reference layer after the pressure applied to the subject and the reference layer is instantaneously increased to a certain pressure.

6. A subject information acquisition apparatus for transmitting an elastic wave to a subject, receiving the elastic wave reflected from inside the subject, and acquiring information inside the subject, the subject information acquisition apparatus comprising:
a conversion device configured to receive the elastic wave and convert the elastic wave into an electrical signal;
a reference layer which is provided between the conversion device and the subject and whose viscosity coefficient and elastic modulus are known;
a measuring unit configured to measure strain of the subject and strain of the reference layer which are generated when a pressure is applied to the subject and the reference layer by using the electrical signal; and
a calculation unit configured to calculate a viscosity coefficient (η) of the subject by using a viscosity coefficient and an elastic modulus of the reference layer, the strain of the subject, and the strain of the reference layer, wherein
a pressure applied to the subject and the reference layer is periodic pressure application including releasing the pressure, and
the calculation unit calculates the viscosity coefficient (η) of the subject by using a delay time between the change over time of the strain value of the subject and the change over time of the strain value of the reference layer which are generated by the periodic pressure application.

7. The subject information acquisition apparatus according to claim 6 , further comprising a control unit configured to display on a display unit a cross-sectional image of inside of the subject based on the electric signals and an image related to viscosity of the subject.

8. The subject information acquisition apparatus according to claim 7 , wherein the control unit displays on the display unit, the cross-sectional image and the image related to viscosity of the subject in parallel, switching, or an overlaid manner.

9. A subject information acquisition apparatus for transmitting an elastic wave to a subject, receiving the elastic wave reflected from inside the subject, and acquiring information inside the subject, the subject information acquisition apparatus comprising:
a conversion device configured to receive the elastic wave and convert the elastic wave into an electrical signal;
a reference layer which is provided between the conversion device and the subject and whose viscosity coefficient and elastic modulus are known;
a measuring unit configured to measure strain of the subject and strain of the reference layer which are generated when a pressure is applied to the subject and the reference layer by using the electrical signal; and
a calculation unit configured to calculate a stress applied to the subject by using the viscosity coefficient and the Young's modulus of the reference layer and the strain of the reference layer, and to further calculate a viscosity coefficient (η) of the subject by using the calculated stress and using an area of a hysteresis loop drawn with strain values of the subject.

10. A method for obtaining a subject information by transmitting an elastic wave to the subject, receiving the elastic wave reflected from inside the subject using a conversion device and converting the received elastic wave into an electric signal, the method comprising:
transmitting to and receiving from the subject, using the conversion device, the elastic wave via a reference layer having a known viscosity coefficient and elastic modulus;
measuring strain of the subject and strain of the reference layer which are generated when a pressure is applied to the subject and the reference layer by using the electrical signal;
calculating a viscosity coefficient (η) of the subject by using a viscosity coefficient and an elastic modulus of the reference layer, the strain of the subject, and the strain of the reference layer;
periodically applying and releasing the pressure to the subject and the reference layer;
wherein
the calculating includes calculating the viscosity coefficient (η) of the subject by using an area of a hysteresis loop drawn with strain values of the subject and strain values of the reference layer which are generated by the periodic pressure.

11. The method according to claim 10 , further comprising:
repeatedly applying and releasing pressure to the subject and the reference layer; wherein
the calculating includes calculating an area of the hysteresis loop for each period, and averaging the calculated areas.

12. The method according to claim 11 , further comprising:
displaying on a display unit a cross-sectional image of inside of the subject based on the electric signals and an image related to viscosity of the subject.

13. The method according to claim 12 , wherein the displaying includes displaying on the display unit, the cross-sectional image and the image related to viscosity of the subject in parallel, switching, or an overlaid manner.

14. A method for obtaining

Assignees

• Oikawa Katsuya
• Nagae Kenichi
• Yamakawa Makoto
• Shiina Tsuyoshi
• Canon Kk

Inventors

• Oikawa Katsuya
• Nagae Kenichi
• Yamakawa Makoto
• Shiina Tsuyoshi

Classifications

• G16H50/30

  for calculating health indices; for individual health risk assessment · CPC title

• G01S7/52042

  determining elastic properties of the propagation medium or of the reflective target (diagnostic techniques involving the measurement of strain A61B8/485) · CPC title

• A61B8/0858 Primary

  involving measuring tissue layers, e.g. skin, interfaces · CPC title

• A61B8/585

  Automatic set-up of the device · CPC title

• A61B8/4483

  characterised by features of the ultrasound transducer · CPC title