Sensor and method for removing interfering substance

Patent metadata

Field	Value
Publication number	US-9651516-B2
Application number	US-201614991018-A
Country	US
Kind code	B2
Filing date	Jan 8, 2016
Priority date	Apr 16, 2010
Publication date	May 16, 2017
Grant date	May 16, 2017

Abstract

A technique is provided, wherein any influence, which would be otherwise exerted on a reaction of an objective substance caused by a reagent enzyme by an interfering substance contained in a specimen, is suppressed in relation to an electrochemical sensor for measuring the objective substance contained in the specimen. A sensor comprises a substrate; a detecting unit which is provided on the substrate and which detects an objective substance; a filter which covers the detecting unit, which permits permeation of the objective substance on one hand, and which regulates permeation of an interfering substance contained in a sample on the other hand; and removing unit which removes the interfering substance adhered to the filter.

First claim

The invention claimed is:

1. A method for removing an interfering substance from a filter of a sensor, where the sensor further comprises a detecting unit provided on a substrate and configured to detect an objective substance present in a sample where the sample is a body fluid, the method comprising:
allowing the interfering substance to adhere to the filter by covering the detecting unit with the filter which permits permeation of the objective substance and which also regulates permeation of the interfering substance present in the sample, and
then removing the interfering substance adhered to the filter by treatment with a removing unit configured to remove the interfering substance,

wherein:
the removing unit comprises at least a pair of removing electrodes which are arranged in mutual contact with the filter or closely to the filter; and
the interfering substance adhered to the filter is removed by applying a voltage between the removing electrodes.

2. The method according to claim 1 , wherein a portion of the sensor is implanted subcutaneously.

3. The method according to claim 1 , wherein the objective substance is selected from the group consisting of glucose, lactic acid and bile acid.

4. The method according to claim 1 , wherein the objective substance is glucose.

5. The method according to claim 1 , wherein the detecting unit comprises a reagent enzyme.

6. The method according to claim 5 , wherein the reagent enzyme is glucose dehydrogenase or glucose oxidase.

7. A sensor for measuring an objective substrate present in a sample, the sensor comprising:
a substrate;
a detecting unit provided on the substrate and configured to detect an objective substance present in a sample, where the sample is a body fluid;
a filter covering the detecting unit and configured to permit permeation of the objective substance while also configured to regulate permeation of an interfering substance present in the sample; and
a removing unit configured to remove the interfering substance adhered to the filter,

wherein:
the removing unit comprises at least a pair of removing electrodes which are arrange in mutual contact with the filter or closely to the filter; and
the interfering substrate adhered to the filter is removed by applying a voltage between the removing elextrodes; and

wherein a portion of the sensor is implanted subcutaneously.

8. The sensor according to claim 7 , wherein the objective substance is glucose.

9. The sensor according to claim 7 , wherein the detecting unit comprises a reagent enzyme.

10. A sensor for measuring an objective substrate present in a sample, the sensor comprising:
a substrate:
a detecting unit provided on the substrate and configured to detect an objective substance present in a sample, where the sample is a body fluid;
a filter covering the detecting unit and configured to permit permeation of the objective substance while also configured to regulate permeation of an interfering substance resent in the sample; and
a removing unit configured to remove the interfering substance adhered to the filter, wherein:
the removing unit comprises at least a pair of removing electrodes which are arranged in mutual contact with the filter or closely to the filter; and
the interfering substrate adhered to the filter is removed by applying a voltage between the removing electrodes; and

wherein the objective substance is selected from the group consisting of glucose, lactic acid and bile acid.

11. The sensor according to claim 10 , wherein the detecting unit comprises a reagent enzyme.

12. The sensor according to claim 9 , or claim 11 , wherein the reagent enzyme is glucose dehydrogenase or glucose oxidase.

Assignees

• Arkray Inc

Inventors

• Shiraki Yasunori
• Katsuki Koji
• Iketani Kazuya

Classifications

• G01N27/3274 Primary

  Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration (coding of calibration information G01N33/48771) · CPC title

• G01N1/34

  Purifying; Cleaning {(processes or apparatus for extracting or separating nucleic acids from biological samples C12N15/1003)} · CPC title

• A61B5/6865

  Access ports · CPC title

• C25F1/00

  Electrolytic cleaning, degreasing, pickling or descaling · CPC title

• G01N27/40

  Semi-permeable membranes or partitions · CPC title