Esterified polysaccharide osmotics

Patent metadata

Field	Value
Publication number	US-9649325-B2
Application number	US-201113053128-A
Country	US
Kind code	B2
Filing date	Mar 21, 2011
Priority date	Mar 19, 2010
Publication date	May 16, 2017
Grant date	May 16, 2017

Abstract

The present invention relates to esterified polysaccharide osmotics, use of same, processes for synthesis of same as well as compositions containing same.

First claim

What is claimed is:

1. A kit configured for the preparation of a dialysis solution, the kit comprising:
a multi-chamber plastic bag comprising a first chamber and a second chamber, wherein the first chamber is separated from said second chamber by a detachable and/or breakable separation system;
a solid composition comprising a starch in solid form contained in the first chamber; and
a second component comprising a solvent, the second component contained in the second chamber;
wherein the dialysis solution is obtained by mixing the solid composition with the second component, the solid composition then being dissolved by said solvent, wherein the solid composition is mixable with the second component after releasing and/or breaking the separation system, thus forming the dialysis solution, and
wherein the starch is esterified at least partially with a citric acid or isocitric acid and wherein the obtained dialysis solution contains the starch esterified at least partially with a citric acid or isocitric acid in a total concentration of 0.001 mM to 10 M.

2. The kit according to claim 1 , wherein the average molecular weight of the starch is between 2000 and 30,000 g/mol.

3. The kit according to claim 1 , wherein the starch comprises a polysaccharide having a degree of polymerization between 10 and 170.

4. The kit according to claim 1 , wherein a 7.5 weight percent aqueous solution of the starch has an osmolarity greater than 11.9 mosm/L.

5. The kit according to claim 1 , wherein the starch comprises a polysaccharide having a degree of substitution between 0.01 and 3.

6. The kit according to claim 1 , wherein the dialysis solution is suitable for hemodialysis or peritoneal dialysis treatment.

7. The kit of claim 1 , further comprising one or more additional components, wherein the dialysis solution is obtained by mixing the solid composition with the second component and with the additional component(s).

Assignees

• Fenn Dominik
• Fichert Thomas
• Schweitzer Thomas
• Bichlmaier Ingo
• Fresenius Medical Care Deutschland Gmbh

Inventors

• Fenn Dominik
• Fichert Thomas
• Schweitzer Thomas
• Bichlmaier Ingo

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P7/08

  Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock (artificial tears A61P27/04) · CPC title

• A61P7/00

  Drugs for disorders of the blood or the extracellular fluid · CPC title

• A61P13/12

  of the kidneys · CPC title

• A61P13/02

  of urine or of the urinary tract, e.g. urine acidifiers · CPC title