Manuka honey microneedle
US-11904125-B2 · Feb 20, 2024 · US
US9649281B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9649281-B2 |
| Application number | US-201514709555-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 12, 2015 |
| Priority date | Nov 13, 2012 |
| Publication date | May 16, 2017 |
| Grant date | May 16, 2017 |
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Official abstract text for this publication.
A transdermal absorption sheet and a manufacturing method for the transdermal absorption sheet includes a laminating step of forming a multilayer film with a viscosity difference by forming, on a support, a lower layer containing a first transdermal absorption material and an upper layer containing a drug and a second transdermal absorption material and having a lower viscosity than the lower layer, a filling step of filling needle-like recessed portions corresponding to inverted needle-like protruding portions with a solution of the transdermal absorption material by pressing a mold in which the needle-like recessed portions are arranged in a two-dimensional array, against a surface of the multilayer film supported by the support to allow the multilayer film to flow, a solidifying step of solidifying the multilayer film with the mold pressed against the surface of the multilayer film, and a peeling-off step of peeling the solidified multilayer film from the mold.
Opening claim text (preview).
What is claimed is: 1. A transdermal absorption sheet in which a plurality of fine needle-like protruding portions are arranged in a two-dimensional array on a surface of a sheet portion supported by a support, wherein a tip of each of the needle-like protruding portions contains a drug and hydroxyethyl starch, and a base of each of the needle-like protruding portions contains hydroxyethyl starch and hyaluronic acid. 2. A transdermal absorption sheet in which a plurality of fine needle-like protruding portions are arranged in a two-dimensional array on a surface of a sheet portion supported by a support, wherein a tip of each of the needle-like protruding portions contains a drug and chondroitin sulfate, and a base of each of the needle-like protruding portions contains hydroxyethyl starch.
Starch; Amylose; Amylopectin; Derivatives thereof · CPC title
Growth hormone [GH], i.e. somatotropin · CPC title
Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof · CPC title
Serum albumin · CPC title
characterised by the choice of material · CPC title
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