Alkoxylated hyperbranched polycarbonates for solubilizing poorly soluble active ingredients

Patent metadata

Field	Value
Publication number	US-9648873-B2
Application number	US-201013514332-A
Country	US
Kind code	B2
Filing date	Dec 3, 2010
Priority date	Dec 9, 2009
Publication date	May 16, 2017
Grant date	May 16, 2017

Abstract

The present invention provides a composition comprising an active ingredient whose solubility in water at 20° C. is not more than 10 g/L, and an amphiphile comprising an alkoxylated hyperbranched polycarbonate, wherein the polycarbonate comprises an alcohol which is a trifunctional or higher polyfunctional polyetherol based on a C 3 -C 12 alkylene oxide and an alcohol which has at least three OH groups. Likewise provided is an amphiphile comprising the polycarbonate, and a process for preparing the amphiphile. The invention further relates to the use of the amphiphile for solubilizing an active ingredient whose solubility in water at 20° C. is not more than 10 g/L, in aqueous solutions, and a method of controlling phytopathogenic fungi and/or unwanted plant growth and/or unwanted insect or mite infestation and/or of regulating the growth of plants.

First claim

The invention claimed is:

1. A composition comprising an active ingredient whose solubility in water at 20° C. is not more than 10 g/L, and an alkoxylated hyperbranched polycarbonate, wherein the polycarbonate comprises a propoxylated alcohol containing 3 to 30 propylene oxide molecules in polymerized form, wherein the propoxylated alcohol is selected from glycerol, trimethylolpropane, 1,2,4-butanetriol, 1,2,3-hexanetriol, 1,2,4-hexanetriol and pentaerythritol, wherein the alkoxylated polycarbonate is alkoxylated with ethylene oxide, and wherein the weight ratio of the propylene oxide to the ethylene oxide is in the range from 3:1 to 1:3.

2. The composition according to claim 1 , wherein the active ingredient comprises an active agrochemical ingredient, active cosmetic ingredient, active pharmaceutical ingredient or nutritional supplement.

3. The composition according to claim 1 , wherein the active ingredient is an active agrochemical ingredient.

4. An amphiphile comprising an alkoxylated hyperbranched polycarbonate, wherein the polycarbonate comprises a propoxylated alcohol containing 3 to 30 propylene oxide molecules in polymerized form, wherein the propoxylated alcohol is selected from glycerol, trimethylolpropane, 1,2,4-butanetriol, 1,2,3-hexanetriol, 1,2,4-hexanetriol and pentaerythritol, wherein the alkoxylated polycarbonate is alkoxylated with ethylene oxide, and wherein the weight ratio of the propylene oxide to the ethylene oxide is in the range from 3:1 to 1:3.

5. A process for preparing the amphiphile according to claim 4 , comprising alkoxylating a hyperbranched polycarbonate using ethylene oxide, wherein the polycarbonate comprises propoxylated alcohol containing 3 to 30 propylene oxide molecules in polymerized form, wherein the propoxylated alcohol is selected from glycerol, trimethylolpropane, 1,2,4-butanetriol, 1,2,3-hexanetriol, 1,2,4-hexanetriol and pentaerythritol.

6. A method for solubilizing an active ingredient, whose solubility in water at 20° C. is not more than 10 g/L, in aqueous solutions, comprising the admixing the active ingredient with the amphiphile according to claim 4 in an aqueous solution.

7. A method of controlling phytopathogenic fungi, unwanted plant growth, or unwanted insect or mite infestation, or of regulating the growth of plants, the composition according to claim 1 is allowed to act on the respective pests, their habitat, or the plants to be protected from the respective pest, the soil, or on unwanted plants or on the crop plants, or on their habitat.

8. The composition of claim 1 , wherein the alcohol which has at least three OH groups is trimethylolpropane.

9. The composition of claim 1 , wherein the weight ratio of propylene oxide to ethylene oxide is in the range from 2.5:1 to 1:2.5.

10. The composition of claim 4 , wherein the alcohol which has at least three OH groups is trimethylolpropane.

11. The composition of claim 4 , wherein the weight ratio of propylene oxide to ethylene oxide is in the range from 2.5:1 to 1:2.5.

Assignees

• Türk Holger
• Haberecht Monika
• Bruchmann Bernd
• Kunst Andreas
• Schönfelder Daniel
• Ishaque Michael
• Basf Se

Inventors

• Türk Holger
• Haberecht Monika
• Bruchmann Bernd
• Kunst Andreas
• Schönfelder Daniel
• Ishaque Michael

Classifications

• C08G64/0216

  containing a chain-terminating or -crosslinking agent · CPC title

• A01N25/30 Primary

  characterised by the surfactants · CPC title

• A01N47/24

  containing the groups [IMAGE cpc-sch-A01N-0944.gif], [IMAGE cpc-sch-A01N-0945.gif] or[IMAGE cpc-sch-A01N-0946.gif]; Thio analogues thereof · CPC title

• C08G64/02 Primary

  Aliphatic polycarbonates · CPC title

• C08L69/00

  Compositions of polycarbonates; Compositions of derivatives of polycarbonates · CPC title