Chimeric clotting factors
US-2015353911-A1 · Dec 10, 2015 · US
Fusion protein having factor VII activity
US9644197B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9644197-B2 |
| Application number | US-201113701333-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 7, 2011 |
| Priority date | Jun 4, 2010 |
| Publication date | May 9, 2017 |
| Grant date | May 9, 2017 |
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- Title
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Abstract
Official abstract text for this publication.
A fusion protein comprising factor VII (FVII) and transferrin according to the present invention has an improved specific activity of FVII compared to existing FVII fusion proteins comprising other fusion partners than transferrin, and thus can be effectively used in a therapy using FVII.
First claim
Opening claim text (preview).
The invention claimed is: 1. A fusion protein comprising factor VII (FVII) and transferrin, wherein said transferrin is linked to the C-terminus of said FVII, and which further comprises a linker between the FVII and the transferrin, and one or more amino acids translated from a restriction enzyme recognition sequence between said C-terminus of said FVII and said transferrin; and wherein the linker comprises a protease cleavage site, which is capable of being cleaved by a protease selected from the group consisting of thrombin, factor Xa, factor IXa, and factor VIIa. 2. The fusion protein of claim 1 , wherein said FVII is a polypeptide represented by the amino acid sequence of SEQ ID NO: 1. 3. The fusion protein of claim 1 , wherein said transferrin is a polypeptide represented by the amino acid sequence of SEQ ID NO: 2. 4. The fusion protein of claim 1 , wherein the linker consists of 1 to 100 amino acids. 5. The fusion protein of claim 1 , wherein the linker consists of 1 to 75 amino acids. 6. The fusion protein of claim 1 , wherein the linker consists of 5 to 25 amino acids. 7. The fusion protein of claim 1 , wherein one or more amino acids translated from the restriction enzyme recognition site are present at one end or both ends of the linker. 8. The fusion protein of claim 1 , wherein the linker is a peptide represented by any one of the amino acid sequences of SEQ ID NOs: 3 to 11.
Assignees
Inventors
Classifications
- C12N9/6437Primary
Coagulation factor VIIa (3.4.21.21) · CPC title
- C07K14/49Primary
Platelet-derived growth factor [PDGF] · CPC title
Fusion polypeptide · CPC title
fusions, other than Fc, for prolonged plasma life, e.g. albumin · CPC title
Coagulation factor VIIa (3.4.21.21) · CPC title
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- What does patent US9644197B2 cover?
- A fusion protein comprising factor VII (FVII) and transferrin according to the present invention has an improved specific activity of FVII compared to existing FVII fusion proteins comprising other fusion partners than transferrin, and thus can be effectively used in a therapy using FVII.
- Who is the assignee on this patent?
- Song In-Young, Kim Hun-Taek, Lee Bong-Yong, and 7 more
- What technology area does this patent fall under?
- Primary CPC classification C12N9/6437. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 09 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).