Bioeffective krill oil compositions

Patent metadata

Field	Value
Publication number	US-9644170-B2
Application number	US-201615180439-A
Country	US
Kind code	B2
Filing date	Jun 13, 2016
Priority date	Mar 28, 2007
Publication date	May 9, 2017
Grant date	May 9, 2017

Abstract

This invention discloses new krill oil compositions characterized by having high amounts of phospholipids, astaxanthin esters and/or omega-3 contents. The krill oils are obtained from krill meal using supercritical fluid extraction in a two stage process. Stage 1 removes the neutral lipid by extracting with neat supercritical CO 2 or CO 2 plus approximately 5% of a co-solvent. Stage 2 extracts the actual krill oils by using supercritical CO 2 in combination with approximately 20% ethanol. The krill oil materials obtained are compared with commercially available krill oil and found to be more bioeffective in a number of areas such as anti-inflammation, anti-oxidant effects, improving insulin resistances and improving blood lipid profile.

First claim

The invention claimed is:

1. A krill oil composition comprising a capsule containing Euphausia superba krill oil suitable for oral administration, said krill oil comprising from 3% to 15% ether phospholipids w/w of said krill oil and astaxanthin esters in amount of greater than about 100 mg/kg of said krill oil.

2. The krill oil composition of claim 1 , wherein said krill oil composition is substantially odorless.

3. The krill oil composition of claim 1 , wherein said krill oil contains astaxanthin esters in an amount of greater than about 200 mg/kg of said krill oil.

4. The krill oil composition of claim 1 , wherein said krill oil comprises at least 30% total phospholipids w/w of said krill oil.

5. The krill oil composition of claim 1 , wherein said krill oil comprises at least 30% phosphatidylcholine w/w of said krill oil.

6. The krill oil composition of claim 1 , wherein said capsule contains a phytonutrient derived from a source other than krill.

7. The krill oil composition of claim 1 , wherein said krill oil further comprises from about 3% to about 10% w/w ether phospholipids; from about 27% to 50% w/w non-ether phospholipids so that the amount of total phospholipids in the composition is from about 30% to 60% w/w; and from about 20% to 50% w/w triglycerides.

8. The krill oil composition of claim 7 , wherein said krill oil further comprises from about 20% to 35% omega-3 fatty acids as a percentage of total fatty acids in said composition.

9. The krill oil composition of claim 1 , wherein said capsule is a soft gel capsule.

10. The krill oil composition of claim 1 , wherein said krill oil comprises less than about 0.45% w/w arachadonic acid.

11. A composition comprising a soft gel capsule containing Euphausia superba krill oil suitable for oral administration, said krill oil comprising from 3% to 15% ether phospholipids w/w of said krill oil and astaxanthin esters in amount of greater than about 100 mg/kg of said krill oil.

12. The composition of claim 11 , wherein said krill oil composition is substantially odorless.

13. The composition of claim 11 , wherein said krill oil contains astaxanthin esters in an amount of greater than about 200 mg/kg of said krill oil.

14. The composition of claim 11 , wherein said krill oil comprises at least 30% total phospholipids w/w of said krill oil.

15. The composition of claim 11 , wherein said krill oil comprises at least 30% phosphatidylcholine w/w of said krill oil.

16. The composition of claim 11 , wherein said krill oil comprises at least 40% phosphatidylcholine w/w of said krill oil.

17. The composition of claim 11 , wherein said capsule contains a phytonutrient derived from a source other than krill.

18. The composition of claim 11 , wherein said krill oil further comprises from about 3% to about 10% w/w ether phospholipids; from about 27% to 50% w/w non-ether phospholipids so that the amount of total phospholipids in the composition is from about 30% to 60% w/w; and from about 20% to 50% w/w triglycerides.

19. The composition of claim 18 , wherein said krill oil further comprises from about 20% to 35% omega-3 fatty acids as a percentage of total fatty acids in said composition.

20. The composition of claim 11 , wherein said krill oil comprises less than about 0.45% w/w arachadonic acid.

Assignees

• Aker Biomarine Antarctic As

Inventors

• Bruheim Inge
• Tilseth Snorre
• Mancinelli Daniele

Classifications

• A61P3/02

  Nutrients, e.g. vitamins, minerals · CPC title

• A61K31/122

  having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin · CPC title

• A61K31/575

  substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol · CPC title

• A61K31/235

  having an aromatic ring attached to a carboxyl group · CPC title

• A61K9/4825

  Proteins, e.g. gelatin (gelatin capsule shells with substantial amounts of other macromolecular substances A61K9/4816) · CPC title