Bioeffective krill oil compositions

Patent metadata

Field	Value
Publication number	US-9644169-B2
Application number	US-201615180431-A
Country	US
Kind code	B2
Filing date	Jun 13, 2016
Priority date	Mar 28, 2007
Publication date	May 9, 2017
Grant date	May 9, 2017

Abstract

This invention discloses new krill oil compositions characterized by having high amounts of phospholipids, astaxanthin esters and/or omega-3 contents. The krill oils are obtained from krill meal using supercritical fluid extraction in a two stage process. Stage 1 removes the neutral lipid by extracting with neat supercritical CO 2 or CO 2 plus approximately 5% of a co-solvent. Stage 2 extracts the actual krill oils by using supercritical CO 2 in combination with approximately 20% ethanol. The krill oil materials obtained are compared with commercially available krill oil and found to be more bioeffective in a number of areas such as anti-inflammation, anti-oxidant effects, improving insulin resistances and improving blood lipid profile.

First claim

The invention claimed is:

1. A method of production of krill oil comprising:
a) providing krill;
b) treating said krill to denature lipases and phospholipases in said krill to provide a denatured krill product;
c) storing said denatured krill product for a storage period of from 1 to 24 months;
d) after said storage period, extracting oil from said denatured krill product with a polar solvent to provide a krill oil with from about 3% to about 15% ether phospholipids w/w of said krill oil astaxanthin esters in amount of greater than about 100 mg/kg of said krill oil.

2. The method of claim 1 , wherein said steps a and b are performed on a ship.

3. The method of claim 1 , wherein said treating comprises heating.

4. The method of claim 1 , wherein said denatured krill product is a krill meal.

5. The method of claim 1 , wherein said krill is freshly harvested.

6. The method of claim 1 , further comprising encapsulating said krill oil.

7. The method of claim 1 , wherein said krill is Antarctic krill.

8. The method of claim 7 , wherein said Antarctic krill is Euphausia superba.

9. The method of claim 1 , wherein said krill oil contains astaxanthin esters in an amount of greater than about 200 mg/kg of said krill oil.

10. The method of claim 1 , wherein said krill oil comprises at least 30% total phospholipids w/w of said krill oil.

11. The method of claim 1 , wherein said krill oil comprises at least 30% phosphatidylcholine w/w of said krill oil.

12. A method of production of krill oil comprising:
a) obtaining a denatured krill product produced by treating freshly harvested krill krill to denature lipases and phospholipases in said krill and that has been stored from 1 to 24 months; and
b) extracting oil from said denatured krill product that has been stored from 1 to 24 months with a polar solvent to provide a krill oil with from about 3% to about 15% ether phospholipids w/w of said krill oil astaxanthin esters in amount of greater than about 100 mg/kg of said krill oil.

13. The method of claim 12 , wherein said treating comprises heating.

14. The method of claim 12 , wherein said denatured krill product is a krill meal.

15. The method of claim 12 , wherein said krill is freshly harvested.

16. The method of claim 12 , further comprising encapsulating said krill oil.

17. The method of claim 12 , wherein said krill is Antarctic krill.

18. The method of claim 17 , wherein said Antarctic krill is Euphausia superba.

19. The method of claim 12 , wherein said krill oil contains astaxanthin esters in an amount of greater than about 200 mg/kg of said krill oil.

20. The method of claim 12 , wherein said krill oil comprises at least 30% total phospholipids w/w of said krill oil.

Assignees

• Aker Biomarine Antarctic As

Inventors

• Bruheim Inge
• Tilseth Snorre
• Mancinelli Daniele

Classifications

• A61P3/02

  Nutrients, e.g. vitamins, minerals · CPC title

• A61K9/4858

  Organic compounds · CPC title

• A61K45/06

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title

• A61K31/685

  one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin · CPC title

• A61K31/683

  Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols · CPC title