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Didemnin biosynthetic gene cluster in Tistrella mobilis
US9644005B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9644005-B2 |
| Application number | US-201214346068-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 21, 2012 |
| Priority date | Sep 21, 2011 |
| Publication date | May 9, 2017 |
| Grant date | May 9, 2017 |
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- Title
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Abstract
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A novel Tistrella mobilis strain having Accession Deposit Number NRRL B-50531 is provided. A method of producing a didemnin precursor, didemnin or didemnin derivative by using the Tistrella mobilis strain, and the therapeutic composition comprising at least one didemnin or didemnin derivative produced from the strain or modified strain thereof are also provided.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of producing a didemnin precursor, didemnin, or didemnin derivative, comprising the steps of: a) culturing a host cell harboring bacterial didemnin synthesis genes; and b) recovering said didemnin precursor, didemnin, or didemnin derivative from said host cell, wherein the host cell is an isolated Tistrella mobilis bacterium having Accession Deposit Number NRRL B-50531 with the depository Agricultural Research Service Culture Collection National Center for Agricultural Utilization Research Agricultural Research Service, U.S. Department of Agriculture. 2. A method of producing a didemnin precursor, didemnin, or didemnin derivative, comprising the steps of: a) culturing a host cell harboring bacterial didemnin synthesis genes; and b) recovering said didemnin precursor, didemnin, or didemnin derivative from said host cell, wherein the host cell is: (i) an isolated Tistrella mobilis bacterium having Accession Deposit Number NRRL B-50531 with the depository Agricultural Research Service Culture Collection National Center for Agricultural Utilization Research Agricultural Research Service, U.S. Department of Agriculture; or (ii) a host cell comprising the polynucleotide sequences of SEQ ID NO:42-51.
Assignees
Inventors
Classifications
- C07K14/195Primary
from bacteria · CPC title
Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms (ergot-alcaloids C12P17/183) · CPC title
Genes encoding for enzymes or proenzymes · CPC title
Chemistry & Metallurgy · mapped topic
- C07K11/02Primary
cyclic, e.g. valinomycins {; Derivatives thereof} · CPC title
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Frequently asked questions
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- What does patent US9644005B2 cover?
- A novel Tistrella mobilis strain having Accession Deposit Number NRRL B-50531 is provided. A method of producing a didemnin precursor, didemnin or didemnin derivative by using the Tistrella mobilis strain, and the therapeutic composition comprising at least one didemnin or didemnin derivative produced from the strain or modified strain thereof are also provided.
- Who is the assignee on this patent?
- Univ King Abdullah Sci & Tech
- What technology area does this patent fall under?
- Primary CPC classification C07K14/195. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 09 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).