Borosilicate glass having improved hydrolytic resistance for preferred use in the pharmaceutical sector

Patent metadata

Field	Value
Publication number	US-9643882-B2
Application number	US-201414263653-A
Country	US
Kind code	B2
Filing date	Apr 28, 2014
Priority date	Apr 26, 2013
Publication date	May 9, 2017
Grant date	May 9, 2017

Abstract

Borosilicate glasses, preferably for use in the pharmaceutical sector, are provided. The borosilicate glasses are outstandingly suitable for the use as pharmaceutical primary packaging, such as phials or ampoules, since the aqueous or water-containing medicaments kept in the containers do not attack the glass significantly, and so the glass releases no, or only few, ions. The borosilicate glasses have the following composition in % by weight or consist thereof:

SiO 2
71-77;

B 2 O 3
9-12;

Al 2 O 3
5.5-8;

Na 2 O
6-8;

K 2 O
0.1-0.9;

Li 2 O
0-0.3;

CaO
0-1.5;

BaO
0-1;

F
0-0.3;

Cl-
0-0.3; and

MgO + CaO + BaO + SrO
0-2.

First claim

What is claimed is:

1. Borosilicate glass comprising the following components in % by weight:

SiO 2
 71-77;

B 2 O 3
10.4-12; 

Al 2 O 3
6.5-8; 

Na 2 O
6.5-8; 

K 2 O
 0.1-0.9;

Li 2 O
   0-0.3;

CaO
   0-1.5;

BaO
 0-1;

F
   0-0.3;

Cl-
   0-0.3;

and

MgO + CaO + BaO + SrO
 0-2.

2. The borosilicate glass according to claim 1 , wherein the K 2 O content is in the range from 0.1 to 0.88% by weight.

3. The borosilicate glass according to claim 1 , wherein the K 2 O content is in the range from 0.2 to 0.75% by weight.

4. The borosilicate glass according to claim 1 , wherein the SiO 2 content is in the range from 72 to 77% by weight.

5. The borosilicate glass according to claim 1 , wherein the SiO 2 content is in the range from >74 to 77% by weight.

6. The borosilicate glass according to claim 1 , wherein the Al 2 O 3 content is 7.2 to 8% by weight.

7. The borosilicate glass according to claim 1 , wherein the Al 2 O 3 content is 6.7 to 7.2% by weight.

8. The borosilicate glass according to claim 1 , wherein the B 2 O 3 content is in the range from 10.5 to 11.5% by weight.

9. The borosilicate glass according to claim 1 , wherein the Li 2 O content is in the range from 0 to 0.2% by weight.

10. The borosilicate glass according to claim 1 , wherein the Li 2 O content is 0.

11. The borosilicate glass according to claim 1 , wherein the CaO content is in the range from 0.1 to 1.3% by weight.

12. The borosilicate glass according to claim 1 , wherein the CaO content is in the range from 0.3 to 0.8% by weight.

13. The borosilicate glass according to claim 1 , wherein the BaO content is in the range from 0.1 to 1.0% by weight.

14. The borosilicate glass according to claim 1 , wherein the ZrO 2 content is in the range from 0 to 2% by weight.

15. The borosilicate glass according to claim 1 , wherein the ZrO 2 content is 0.

16. The borosilicate glass according to claim 1 , wherein the ZnO content is in the range from 0 to 0.6% by weight.

17. The borosilicate glass according to claim 1 , wherein the ZnO content is in the range from 0.15 to 0.45% by weight.

18. The borosilicate glass according to claim 1 , further comprising characterized a thermal expansion coefficient α 20/300 is in the range from 4.8×10 −6 /K to 5.6×10 −6 /K.

19. The borosilicate glass according to claim 1 , wherein the glass is free from As 2 O 3 and Sb 2 O 3 except for unavoidable impurities.

20. A tube comprising the borosilicate glass according to claim 1 that is drawn using a Danner drawing process.

21. A pharmaceutical primary packaging device comprising the borosilicate glass according to claim 1 .

22. The borosilicate glass according to claim 1 , wherein the CaO content is in the range of 0 to 0.3% by weight and the B 2 O 3 content is in the range of 11.5 to 12% by weight.

Assignees

• Schott Ag

Inventors

• Tratzky Stephan
• Kass Christof
• Eichholz Rainer
• Nass Peter

Classifications

• C03C4/20

  for chemical resistant glass · CPC title

• A61J1/00

  Containers specially adapted for medical or pharmaceutical purposes (capsules or the like for oral use A61J3/07; specially adapted for surgical or diagnostic appliances or instruments A61B50/30; containers for radioactive substances G21F5/00) · CPC title

• C03C3/11

  containing halogen or nitrogen · CPC title

• C03C3/118

  containing aluminium · CPC title

• C03C3/093 Primary

  containing zinc or zirconium · CPC title