Bone regeneration material kit, paste-like bone regeneration material, bone regeneration material, and bone bonding material

Patent metadata

Field	Value
Publication number	US-9642934-B2
Application number	US-201414910183-A
Country	US
Kind code	B2
Filing date	Aug 8, 2014
Priority date	Aug 9, 2013
Publication date	May 9, 2017
Grant date	May 9, 2017

Abstract

The present invention aims to provide a bone regeneration material kit, a paste-like bone regeneration material, a bone regeneration material, and a bone bonding material, which contain particles including a bioabsorbable polymer; and can fill a bone defect or damage and secure the mechanical strength of the bone in the short term and can promote regeneration of the patient's own bone in the long term. In addition, they can exhibit anti-washout properties after filling even when they are in contact with water such as blood or biological fluids. The present invention relates to a bone regeneration material kit comprising: a particle comprising a calcium salt and having an inositol phosphate or salt thereof adsorbed on the surface; a particle comprising a bioabsorbable polymer; and an aqueous medium.

First claim

The invention claimed is:

1. A bone regeneration material kit comprising:
a particle comprising a calcium salt and having an inositol phosphate or salt thereof adsorbed on the surface;
a particle comprising a calcium phosphate compound and having no inositol phosphate or salt thereof adsorbed on the surface;
wherein a blend ratio of the particle comprising a calcium salt and having an inositol phosphate or salt thereof adsorbed on the surface and the particle comprising a calcium phosphate compound and having no inositol phosphate or salt thereof adsorbed on the surface is within the range of 10:90 to 50:50 by weight;
a particle comprising a bioabsorbable polymer; and
an aqueous medium.

2. The bone regeneration material kit according to claim 1 ,
wherein the inositol phosphate or salt thereof is inositol hexaphosphate.

3. The bone regeneration material kit according to claim 1 ,
wherein the particle comprising a bioabsorbable polymer is a particle comprising crosslinked gelatin.

4. The bone material regeneration kit of claim 1 , wherein the calcium salt is a hydroxyapatite.

5. The bone material regeneration kit of claim 1 , wherein the calcium phosphate compound comprises α-tricalcium phosphate and β-tricalcium phosphate.

6. A paste-like bone regeneration material comprising the bone regeneration material kit according to claim 1 ,
the paste-like bone regeneration material being a paste prepared by mixing the particle comprising a calcium salt and having an inositol phosphate or salt thereof adsorbed on the surface; the particle comprising a calcium phosphate compound and having no inositol phosphate or salt thereof adsorbed to the surface, the particle comprising a bioabsorbable polymer; and the aqueous medium.

7. A bone regeneration material prepared by curing the paste-like bone regeneration material according to claim 6 .

Assignees

• Gunze Kk
• Univ Meiji
• Kanagawa Acad Of Science And Tech

Inventors

• KIMINAMI Keishi
• Arimura Hidetoshi
• Aizawa Mamoru
• Mizumoto Minori
• KONISHI Toshiisa

Classifications

• A61L27/54

  Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)} · CPC title

• A61L2300/412

  Tissue-regenerating or healing or proliferative agents · CPC title

• A61L27/58

  Materials at least partially resorbable by the body · CPC title

• A61L27/222

  Gelatin · CPC title

• A61L2430/02

  for reconstruction of bones; weight-bearing implants · CPC title