Carboxylmethyl cellulose foam for hemostasis and wound treatment, and method for preparing same

Patent metadata

Field	Value
Publication number	US-9642929-B2
Application number	US-201314782843-A
Country	US
Kind code	B2
Filing date	Nov 20, 2013
Priority date	Apr 8, 2013
Publication date	May 9, 2017
Grant date	May 9, 2017

Abstract

The present invention relates to a highly liquid absorbent and hardly water-soluble carboxymethyl cellulose (CMC) foam, which absorbs body fluid or water, expands in volume when absorbing liquid, does not gelate, and maintains shape. The hardly water-soluble CMC foam prepared according to the preparation method of the present invention has remarkably superior liquid absorption property, shows large volume expansibility when absorbing liquid, does not gelate, and maintains shape. Therefore, a remarkably improved ability is shown when used as a hemostatic agent and a wound dressing. In addition, when the CMC foam is treated with a CMC powder dispersing liquid, the surface characteristics change, thereby preventing adhesion with the skin and improving liquid retention capability. Thus, it is possible to control the liquid absorption property thereof to meet the desired purpose.

First claim

What is claimed is:

1. A water-insoluble carboxymethyl cellulose foam that does not gelate when absorbing liquid, wherein the foam has a degree of liquid absorption of 20 g/g or higher when applied a 0.9% saline solution, and has a 2-fold or higher expansion in volume after absorption of the saline solution compared to that before absorbing the saline solution.

2. The foam of claim 1 , wherein the foam has a 3-fold or higher expansion in volume after absorption of the saline solution compared to that before absorbing the saline solution.

3. The foam of claim 1 , wherein the foam has a 4-fold or higher expansion in volume after absorption of the saline solution compared to that before absorbing the saline solution.

4. A method of preparing the water-insoluble carboxymethyl cellulose foam that does not gelate when absorbing liquid, according to claim 1 , the method comprising:
(1) preparing a carboxymethyl cellulose foam by freeze-drying a solution in which 1 wt % to 2 wt % of carboxymethyl cellulose powder is dissolved;
(2) acid-treating the foam prepared in step (1) by immersing the foam in an acid solution, and then heating; and
(3) compressing the acid-treated foam in step (2) at 60° C. or below.

5. The method of claim 4 , wherein the carboxymethyl cellulose solution in step (1) is an aqueous solution.

6. The method of claim 4 , wherein the heating in step (2) is performed at from 40° C. to 70° C.

7. The method of claim 4 , wherein the acid solution is prepared by adding an acid to a mixture containing an alcohol and water or adding an acid to an alcohol, and the acid is at least one selected from the group consisting of lactic acid, acetic acid, citric acid, succinic acid, formic acid, and hydrochloric acid.

8. The method of claim 7 , wherein the volume of the alcohol in the mixture containing an alcohol and water accounts for 60% to 100% of the total volume of the mixture.

9. The method of claim 4 , further comprising step (2-1) of immersing the acid-treated foam in the dispersion containing carboxymethyl cellulose powder in liquid, between step (2) and step (3).

10. The method of claim 9 , wherein the liquid is selected from the group consisting of ethanol, methanol, and isopropanol.

11. The method of claim 4 , wherein the foam has a 3-fold or higher expansion in volume after absorption of the saline solution compared to that before absorbing the saline solution.

12. The method of claim 4 , wherein the foam has a 4-fold or higher expansion in volume after absorption of the saline solution compared to that before absorbing the saline solution.

13. A water-insoluble carboxymethyl cellulose foam that does not gelate when absorbing liquid, prepared by (i) freeze-drying a solution of carboxymethyl cellulose, thereby forming a carboxymethyl cellulose foam, (ii) acid-treating the carboxymethyl cellulose foam, thereby forming the water-insoluble carboxymethyl cellulose foam, and (iii) compressing the water-insoluble foam.

14. The foam of 13 , wherein the water-insoluble carboxymethyl cellulose foam further comprises carboxymethyl cellulose powder in pores thereof, thereby improving the degree of liquid absorption or the degree of liquid absorption under pressure.

15. The foam of 13 , wherein the degree of substitution of the carboxymethyl cellulose powder is 0.4 or higher.

Assignees

• Korea Ind Tech Inst

Inventors

• Im Jung Nam
• Doh Song Jun
• Kim Tae Hee
• Yoon Min Ji
• Kim Chae Hwa

Classifications

• A61L15/60

  Liquid-swellable gel-forming materials, e.g. super-absorbents · CPC title

• A61L15/425

  Porous materials, e.g. foams or sponges · CPC title

• A61F13/15203

  Properties of the article, e.g. stiffness or absorbency (chemical aspects A61L15/00) · CPC title

• C08L1/26

  Cellulose ethers · CPC title

• A61L15/28 Primary

  Polysaccharides or their derivatives {(A61L15/225 takes precedence)} · CPC title