Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin amyloidosis and protein-protein interactions

Patent metadata

Field	Value
Publication number	US-9642838-B2
Application number	US-201514876447-A
Country	US
Kind code	B2
Filing date	Oct 6, 2015
Priority date	Dec 21, 2012
Publication date	May 9, 2017
Grant date	May 9, 2017

Abstract

Disclosed herein are compounds and compositions thereof which find use in increasing stability of proteins particularly proteins that tend to misfold and form aggregates. Also provided herein are methods for using these compounds and compositions for increasing stability of proteins and thereby decreasing aggregate formation by these proteins. Also disclosed herein are heterobifunctional compounds that include a TTR binding compound connected to a targeting moiety via a linker, for use in disrupting PPIs of a target protein.

First claim

What is claimed is:

1. A compound having the formula VIIc

2. A compound having the formula VIIc

or a pharmaceutically acceptable salt thereof.

3. A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically acceptable excipient.

4. A pharmaceutical composition comprising the compound or pharmaceutically acceptable salt of claim 2 and a pharmaceutically acceptable excipient.

Assignees

• Univ Leland Stanford Junior
• The Board Of Trustees Of The Leland Standford Junior Univ

Inventors

• Graef Isabella A
• Alhamadsheh Mamoun M

Classifications

• A61P35/00

  Antineoplastic agents · CPC title

• A61P9/00

  Drugs for disorders of the cardiovascular system · CPC title

• A61P5/14

  of the thyroid hormones, e.g. T3, T4 · CPC title

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P3/10

  for hyperglycaemia, e.g. antidiabetics · CPC title