Composition comprising oil palm phenolics for use in providing neuroprotective effects and cognitive-enhancement

Patent metadata

Field	Value
Publication number	US-9642389-B2
Application number	US-201013145101-A
Country	US
Kind code	B2
Filing date	Jan 29, 2010
Priority date	Jan 29, 2009
Publication date	May 9, 2017
Grant date	May 9, 2017

Abstract

The present invention relates to a composition comprising oil palm phenolics for use in providing neuroprotective effects and improving cognitive and motor functions abilities.

First claim

The invention claimed is:

1. A method for up-regulating at least one gene involved in neuroprotection in the brain of a subject in need thereof, the method comprising:
administering to said subject a composition comprising an effective amount of an extract from oil palm vegetation liquor, wherein said extract contains a mixture of phenolic compounds, fruit adds, fruit sugars and glycerol, wherein said extract contains an antioxidant content of about 1500 ppm gallic add equivalent;
wherein the amount of the composition administered is sufficient to up-regulate at least one gene involved in neuroprotection, wherein the gene is selected from the group consisting of Arc, Cast, Gria 3 , Kcnb 1 , Kcnab 1 , Homer 1 , Dlgap 2 , Dlgh 4 , Sv 2 b , Stx 1 a , Gucylb 3 , Ncald, Bzrap 1 , Pelo, Ptprn, Ptprt, Fas, Egr 1 , and Egr 4 ; and
wherein said composition is administered in the form of doses on a daily, weekly or monthly basis for a predetermined period of time, thereby providing neuroprotection in the brain of said subject.

2. The method of claim 1 , wherein the subject has at least one neurodegenerative disease or a disease related thereto.

3. The method of claim 1 , wherein the composition improves cognitive and motor functions in the subject.

4. The method of claim 1 , wherein the composition is administered in a dose dependent manner.

5. The method of claim 1 , wherein the composition is administered in a liquid dosage form.

6. The method of claim 1 , wherein the composition is administered in a pharmaceutically effective form.

7. The method of claim 1 , wherein the composition is administered in a nutraceutical form.

8. The method of claim 1 , wherein the composition is administered in a nutritional supplementary form.

9. The method of claim 1 , wherein the composition is administered in a suppository form.

10. The method of claim 1 , wherein the composition is administered in a form suitable for oral administration.

11. The method of claim 1 , wherein the composition is administered in a form suitable for intravenous administration.

12. A method of reducing inflammation in the brain of a patient having a neurodegenerative disease, the method comprising:
administering to said patient a composition comprising an effective amount of an extract from oil palm vegetation liquor, wherein said extract contains a mixture of phenolic, compounds, fruit adds, fruit sugars and glycerol, wherein said extract contains an antioxidant content of about 1500 ppm gallic add equivalent;
wherein at least one gene involved in acute phase response, aldehyde metabolism, hormone-mediated signaling, lipid metabolism, oxidoreductase activity, prostaglandin synthesis regulation, tumor necrosis factor-alpha/nuclear factor-kappaB (TNF-alpha/NF-kappaB) signaling, focal adhesion, and/or amino add metabolism is down-regulated; and
wherein said composition is administered in the form of doses on a daily, weekly or monthly basis for a predetermined period of time, thereby reducing inflammation in the brain of the patient.

13. The method of claim 12 , wherein the composition improves cognitive and motor functions in the patient.

14. The method of claim 12 , wherein the composition is administered in a dose dependent manner.

15. The method of claim 12 , wherein the composition is administered in a liquid dosage form.

16. The method of claim 12 , wherein the composition is administered in a pharmaceutically effective form.

17. The method of claim 12 , wherein the composition is administered in a nutraceutical form.

18. A method for up-regulating tyrosine phosphatase and/or ionotropic glutamate receptor genes, and/or down-regulating at least one gene from the group consisting actin, Hoxa 5 , and Hoxb 5 in the brain of a subject suffering from Alzheimer's Disease, the method comprising:
administering to said subject a composition comprising an effective amount of an extract from oil palm vegetation liquor, wherein said extract contains a mixture of phenolic compounds, fruit acids, fruit sugars and glycerol, wherein said extract contains an antioxidant content of about 1500 ppm gallic acid equivalent; and
wherein said composition is administered in the form of doses on a daily, weekly or monthly basis for a predetermined period of time, thereby up-regulating tyrosine phosphatase and/or ionotropic glutamate receptor genes, and/or down-regulating at least one gene from the group consisting actin, Hoxa 5 , and Hoxb 5 in the brain of said subject.

Assignees

• Sambanthamurthi Ravigadevi
• Leow Soon-Sen
• Tan Yew Ai
• Manickam Kalyana Sundram P
• Wahid Mohd Basri
• Malaysian Palm Oil Board

Inventors

• Sambanthamurthi Ravigadevi
• Leow Soon-Sen
• Tan Yew Ai
• Manickam Kalyana Sundram P
• Wahid Mohd Basri

Classifications

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title

• A61P25/28

  for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia · CPC title

• A61P25/16

  Anti-Parkinson drugs · CPC title

• A61P25/00

  Drugs for disorders of the nervous system · CPC title

• A23L33/105 Primary

  Plant extracts, their artificial duplicates or their derivatives · CPC title