Bi-Specific Fusion Proteins
US-2024101713-A1 · Mar 28, 2024 · US
Selective cartilage therapy
US9637531B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9637531-B2 |
| Application number | US-201314409312-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 25, 2013 |
| Priority date | Jun 25, 2012 |
| Publication date | May 2, 2017 |
| Grant date | May 2, 2017 |
How to read this patent
A practical reading order for non-experts. Skip the full description unless you need deep technical detail.
- Title
What the patent document calls the invention.
- Abstract
A short plain-language summary of the technical disclosure.
- Assignees and inventors
Who owns or filed the patent and who is credited as inventor.
- Key dates
Filing, priority, publication, and grant dates set the timeline.
- First independent claim
The legal scope of protection — read this for what is actually claimed.
- CPC / IPC classifications
Technology tags used to group this patent with similar filings.
- Citations and related patents
Prior art links and similar publications in this corpus.
Abstract
Official abstract text for this publication.
The present invention relates to compositions, methods and kits for delivery of an IGF-1 protein or a functional fragment or variant, derivative thereof to cells or tissues that express proteoglycans. More specifically, the present invention relates to fusion proteins comprising a heparin binding protein (HB) comprising SEQ ID NO: 1 or SEQ ID NO: 2. Other aspects relate to use of a HB-IGF-1 fusion proteins in methods to deliver IGF-1 to the cartilage for the treatment of a cartilage related disease and disorder in a subject.
First claim
Opening claim text (preview).
The invention claimed is: 1. A composition comprising a HB-X fusion protein, wherein HB is a heparin binding peptide having the amino acid sequence (MKRKKKGKGLGKKRDPSLRKYK) (SEQ ID NO:1) or (KRKKKGKGLGKKRDPSLRKYK) (SEQ ID NO:2), and X is Insulin-like growth factor 1 (IGF-1), and further wherein the IGF-1 is a human IGF-1. 2. A composition comprising a HB-X fusion protein, wherein HB is a heparin binding peptide having the amino acid sequence (MKRKKKGKGLGKKRDPSLRKYK) (SEQ ID NO:1) or (KRKKKGKGLGKKRDPSLRKYK) (SEQ ID NO:2), and Xis Insulin-like growth factor 1 (IGF-1), wherein the IGF-1 comprises the amino acid sequence of SEQ ID NO: 4, 5, 6 or 7. 3. A composition comprising a HB-X fusion protein, wherein HB is a heparin binding peptide having the amino acid sequence (MKRKKKGKGLGKKRDPSLRKYK) (SEQ ID NO:1) or (KRKKKGKGLGKKRDPSLRKYK) (SEQ ID NO:2), and Xis Insulin-like growth factor 1 (IGF-1), wherein the HB-X fusion protein comprises amino acids of SEQ ID NO: 13 or SEQ ID NO: 15.
Assignees
Inventors
Classifications
for non-specific disorders of the connective tissue · CPC title
- C07K14/65Primary
Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2 · CPC title
Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2 {(insulin-like growth factor binding protein A61K38/1754)} · CPC title
from mammals · CPC title
Fusion polypeptide · CPC title
Patent family
Related publications grouped by family.
External sources
Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US9637531B2 cover?
- The present invention relates to compositions, methods and kits for delivery of an IGF-1 protein or a functional fragment or variant, derivative thereof to cells or tissues that express proteoglycans. More specifically, the present invention relates to fusion proteins comprising a heparin binding protein (HB) comprising SEQ ID NO: 1 or SEQ ID NO: 2. Other aspects relate to use of a HB-IGF-1 fus…
- Who is the assignee on this patent?
- Brigham & Womens Hospital Inc, Brigham & Womens Hospital Inc
- What technology area does this patent fall under?
- Primary CPC classification C07K14/65. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 02 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).