Sample handling system

Patent metadata

Field	Value
Publication number	US-9636680-B2
Application number	US-201314376123-A
Country	US
Kind code	B2
Filing date	Feb 1, 2013
Priority date	Feb 3, 2012
Publication date	May 2, 2017
Grant date	May 2, 2017

Abstract

Sample handling system for handling samples contained in tubes ( 4 ), each tube ( 4 ) having a hollow body, a closed bottom and an open top for accessing the sample contained in the tube ( 4 ). The system comprises a micro-plate ( 1 ) comprising at least one grid insert ( 2 ) having a plurality of compartments. Each compartment comprises one or more side walls laterally confining a through-hole for receiving a said tube ( 4 ). The through-hole has a top opening and a bottom opening and extends between the top opening and the bottom opening. A frame ( 3 ) to which the at least one separate grid insert ( 2 ) is to be attached to form the micro-plate ( 1 ). The frame ( 3 ) laterally confines a through-opening which is dimensioned to allow for accessing each compartment ( 21 ) of the attached at least one grid insert ( 2 ) from above and from below. This allows for moving such tube ( 4 ) into and out of each compartment ( 21 ) through each of the top opening ( 202 ) and the bottom opening ( 203 ) of the through-hole ( 201 ).

First claim

The invention claimed is:

1. A sample handling system for handling samples contained in
tubes, each tube having a hollow body, a closed bottom and an open top for accessing the sample contained in the tube, the system including a micro-plate comprising:
at least one separate grid insert and at least one further separate grid insert forming a stack of connected grid inserts arranged one above the other in the stack, each of the at least one separate grid insert and the at least one further separate grid insert having a plurality of compartments, each compartment including one or more side walls laterally confining a through-hole, wherein the through-hole has a top opening and a bottom opening and extends between the top opening and the bottom opening, and
a frame to which only an uppermost one of the at least one separate grid insert and the at least one further separate grid insert of the stack is attached to form the microplate, the frame laterally confining a single through-opening dimensioned to allow for accessing from above each compartment of the uppermost separate grid insert in the stack of connected grid inserts that is attached to the frame and accessing from below each compartment of a lowermost separate grid insert in the stack of connected grid inserts, and to allow for moving a tube into and out of each compartment through each of the top opening and the bottom opening of the through-hole,
wherein:
each of the at least one separate grid insert and the at least one further separate grid insert includes one or more stacking elements for connecting the at least one separate grid insert and the at least one further separate grid insert to form the stack of connected grid inserts,
each stacking element includes at least one resilient locking member extending downwardly beyond a corresponding one of the at least one separate grid insert and the at least one further separate grid insert and further includes at least one notch arranged to lockingly receive the at least one resilient locking member of an above-arranged separate grid insert that is one of the at least one further separate grid insert or the at least one separate grid insert, respectively, and
each compartment in each of the at least one separate grid insert is longitudinally aligned with a compartment of the at least one further separate grid insert in the stack to form a joint through-hole through which a tube is moveable.

2. A sample handling system according to claim 1 , wherein at least one of the frame, the at least one separate grid insert, and the at least one further separate grid insert comprise fastening elements for fixedly attaching the uppermost one of the at least one separate grid insert and the at least one further separate grid insert of the stack to the frame.

3. A sample handling system according to claim 2 , wherein the fastening elements for fixedly attaching the uppermost one of the at least one separate grid insert and the at least one further separate grid insert of the stack to the frame comprise one or more protrusions arranged on a resilient portion of the inner wall of the frame and one or more recesses arranged on a portion of the outer wall of the uppermost one of the at least one separate grid insert and the at least one further separate grid insert such that the one or more protrusions lockingly engage with the one or more recesses of the uppermost separate grid insert in the stack of connected grid inserts when the stack is inserted into the frame from below.

4. A sample handling system according to claim 1 , wherein the frame has an insertion height greater than or equal to the overall height of the stack.

5. A sample handling system according to claim 1 , wherein one or both of the at least one separate grid insert and the at least one further separate grid insert comprise a machine-readable identification label for identifying the at least one separate grid insert or the at least one further separate grid insert and the tubes received in one or both of the at least one separate grid insert and the at least one further separate grid insert.

6. A sample handling system according to claim 5 , wherein the frame has a recessed section adjacent to a position of the machine-readable identification label.

7. A sample handling system according to claim 1 , wherein each compartment of the at least one separate grid insert or the at least one further separate grid insert comprises a circumferential projection extending inwardly from the one or more side walls confining the through-hole.

8. A sample handling system according to claim 1 , wherein the system further comprises tubes, each tube having an abutment portion at the lower end of the tube and a circumferential rim at an open top of the tube, the abutment portion at the lower end of the tube being capable of abutting against the circumferential rim of another tube arranged in the longitudinally aligned compartment of the at least one separate grid insert or the at least one further separate grid insert underneath the tube.

9. A sample handling system according to claim 8 , wherein the tube on its outer wall comprises a circumferentially running groove having a width extending in the axial direction and a circumferentially extending ledge which forms the upper boundary of the circumferentially running groove.

10. A sample handling system according to claim 1 , wherein the system further comprises a storage tray comprising a plurality of storage compartments, each storage compartment being capable of only accommodating at least one of the at least one separate grid insert and the at least one further separate grid insert of the stack without the frame, which is separable from the uppermost one of the at least one separate grid insert and the at least one further separate grid insert of the stack.

11. A sample handling system according to claim 10 , wherein the storage compartments of the storage tray have a depth such that they are capable of accommodating all separate grid inserts of the stack of connected grid inserts.

12. A sample handling system according to claim 10 , wherein the tray comprises position markers thereon at locations of the storage compartments for indicating a position of the at least one separate grid insert or the at least one further separate grid insert.

13. A sample handling system according to claim 11 , wherein the storage tray comprises position markers thereon at locations of the storage compartments for indicating the position of all separate grid inserts of the stack of connected grid inserts.

14. A sample handling system according to claim 1 , wherein the system further comprises tubes of different lengths accommodated in the plurality of compartments, wherein the respective longitudinally aligned compartments forming the joint through-holes are configured such that each tube of the tubes of different lengths is completely immersed within the stack of connected grid inserts.

Assignees

• Hoffmann La Roche
• Hoffmann La Roche

Inventors

• Fattinger Christof
• Kissling Tom
• Zumstein Thomas

Classifications

• B01L3/00

  Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers · CPC title

• B01L2300/044

  pierceable, e.g. films, membranes · CPC title

• G01N2035/041

  lifting items out of a rack for access · CPC title

• B01L2300/0829

  Multi-well plates; Microtitration plates · CPC title

• G01N2035/0405

  manipulating closing or opening means, e.g. stoppers, screw caps, lids or covers · CPC title