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Composition, method, system and kit for optical electrophysiology
US9636424B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9636424-B2 |
| Application number | US-201615159376-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 19, 2016 |
| Priority date | Oct 24, 2006 |
| Publication date | May 2, 2017 |
| Grant date | May 2, 2017 |
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- Title
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Abstract
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The present invention provides a method of optical electrophysiological probing, including: providing a fluorescing chemical probe; contacting a thick portion of tissue with the fluorescing chemical probe to create a thick portion of treated tissue; applying a first range of wavelengths of electromagnetic radiation to the treated portion of tissue; and detecting a plurality of depth-specific emission wavelengths emitted from the thick portion of treated tissue.
First claim
Opening claim text (preview).
The invention claimed is: 1. An optically mapping composition comprising a voltage-sensitive dye of the formula: wherein R 1 is a first hydrocarbon group that is a butyl group; R 2 is a second hydrocarbon group that is a butyl group; and R 3 is a trimethylpropyl ammonium polar group. 2. The composition of claim 1 , having the formula: 3. The composition of claim 1 , further comprising a delivery agent that is at least one of a physiologically acceptable adjuvant, solvent, substrate, or diluent. 4. The composition of claim 3 , wherein the delivery agent is selected from the group consisting of: Pluronic F-127, Pluronic L64, cyclodextrin, gamma cyclodextrin, dimethylsulfoxide, ethanol, and combinations thereof.
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Classifications
- A61K49/0032Primary
Methine dyes, e.g. cyanine dyes · CPC title
- C09B23/0075Primary
the polymethine chain being part of an heterocyclic ring · CPC title
Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" (in vivo A61B5/00; immunoassay G01N33/53) · CPC title
Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers · CPC title
characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules · CPC title
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- What does patent US9636424B2 cover?
- The present invention provides a method of optical electrophysiological probing, including: providing a fluorescing chemical probe; contacting a thick portion of tissue with the fluorescing chemical probe to create a thick portion of treated tissue; applying a first range of wavelengths of electromagnetic radiation to the treated portion of tissue; and detecting a plurality of depth-specific em…
- Who is the assignee on this patent?
- The Res Found Of State Univ Of New York, Univ Connecticut, Univ Connecticut
- What technology area does this patent fall under?
- Primary CPC classification A61K49/0032. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue May 02 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).