Drug delivery compositions

Patent metadata

Field	Value
Publication number	US-9631177-B2
Application number	US-201113881982-A
Country	US
Kind code	B2
Filing date	Oct 26, 2011
Priority date	Oct 27, 2010
Publication date	Apr 25, 2017
Grant date	Apr 25, 2017

Abstract

The present invention relates material that is useful in drug delivery compositions. The material comprises cellulose nanofibers and/or derivatives thereof, wherein the cellulose nanofibers are in a form of a hydrogel or membrane. The invention also provides methods for producing these materials and compositions and uses thereof.

First claim

The invention claimed is:

1. A drug delivery composition, characterized in that the composition comprises plant derived cellulose nanofibers and/or derivatives thereof and a drug or medicament, wherein the plant derived cellulose nanofibers and/or derivatives thereof are in the form of a hydrogel and said cellulose nanofibers are obtained by mechanical disintegration, said hydrogel being a direct product of homogenization of said cellulose nanofibers, wherein the delivery of the drug or medicament is controlled by diffusion through the hydrogel.

2. The composition according to claim 1 , characterized in that the cellulose nanofiber derivatives comprise chemically or physically modified derivatives of cellulose nanofibers or nanofiber bundles.

3. The composition according to claim 1 , characterized in that the composition is a topical, subcutaneous, intramuscular or intraocular composition.

4. The composition according to claim 1 , wherein the drug or medicament is incorporated in the hydrogel as an aqueous solution or dispersion.

5. The composition according to claim 1 , wherein the composition comprises about 0.05-20 wt percent of cellulose nanofibers and about 0.001-20 wt percent of the drug or medicament and water.

6. The composition according to claim 1 , wherein the composition is injectable.

7. The composition according to claim 6 , wherein the plant derived cellulose is native grade.

8. The composition of claim 1 , wherein the cellulose nanofibers are configured to form a gel network at 0.5% by weight.

9. The composition of claim 1 , wherein the composition comprises 0.5-4% by weight of plant derived cellulose nanofibers and/or derivatives thereof.

10. The composition of claim 1 , wherein the diameter of cellulose nanofibers and/or derivatives thereof or nanofiber bundles in the cellulose nanofibers is less than 200 nm.

11. The composition of claim 1 , wherein the diameter of cellulose nanofibers and/or derivatives thereof or nanofiber bundles in the cellulose nanofibers is less than 100 nm.

12. The composition of claim 1 , wherein the diameter of the cellulose nanofibers and/or derivatives thereof is less than 1 μm.

13. The composition of claim 1 , wherein the hydrogel is configured to be used without any substantial modifications in drug delivery in vivo.

14. The composition of claim 1 , wherein the storage modulus of the hydrogel is at least one order of magnitude higher than the loss modulus of the hydrogel.

15. The composition of claim 1 , wherein the hydrogel is opaque, and the homogenization includes high pressure homogenization of the cellulose nanofibers, the cellulose nanofibers being wet cellulose nanofibers.

16. The composition of claim 1 , wherein the hydrogel is transparent, and the cellulose nanofibers are chemically modified.

Assignees

• Yliperttula Marjo
• Laurén Patrick
• Bhattacharya Madhushree
• Lou Yanru
• Laukkanen Antti
• Upm Kymmene Corp

Inventors

• Yliperttula Marjo
• Laurén Patrick
• Bhattacharya Madhushree
• Lou Yanru
• Laukkanen Antti

Classifications

• C08J2301/02

  Cellulose; Modified cellulose · CPC title

• C12N11/12

  Cellulose or derivatives thereof · CPC title

• C12N5/067

  Hepatocytes · CPC title

• A61L27/20

  Polysaccharides · CPC title

• A61L27/52

  Hydrogels or hydrocolloids · CPC title