Self-Assembling Protein Nanostructures
US-2015356240-A1 · Dec 10, 2015 · US
Polypeptides for use in self-assembling protein nanostructures
US9630994B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9630994-B2 |
| Application number | US-201514930792-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 3, 2015 |
| Priority date | Nov 3, 2014 |
| Publication date | Apr 25, 2017 |
| Grant date | Apr 25, 2017 |
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- Title
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Abstract
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Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using such synthetic nanostructures are disclosed herein.
First claim
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We claim: 1. An isolated polypeptide comprising an amino acid sequence that is at least 75% identical over its length, and identical at least at one identified interface position, to the amino acid sequence of a polypeptide selected from the group consisting of SEQ ID NOS:1-34: Identified interface Name Amino Acid Sequence residues I53-34A MEGMDPLAVLAESRLLPLLTVRGGE I53-34A: SEQ ID DLAGLATVLELMGVGALEITLRTEK 28,32,36, NO: 1 GLEALKALRKSGLLLGAGTVRSPKE 37,186, AEAALEAGAAFLVSPGLLEEVAALA 188,191, QARGVPYLPGVLTPTEVERALALGL 192,195 SALKFFPAEPFQGVRVLRAYAEVFP EVRFLPTGGIKEEHLPHYAALPNLL AVGGSWLLQGDLAAVMKKVKAAKAL LSPQAPG I53-34B MTKKVGIVDTTFARVDMAEAAIRTL I53-34B: SEQ ID KALSPNIKIIRKTVPGIKDLPVACK 19,20,23, NO: 2 KLLEEEGCDIVMALGMPGKAEKDKV 24,27, CAHEASLGLMLAQLMTNKHIIEVFV 109,113, HEDEAKDDDELDILALVRAIEHAAN 116,117, VYYLLFKPEYLTRMAGKGLRQGRED 120,124, AGPARE 148 I53-40A MTKKVGIVDTTFARVDMASAAILTL I53-40A: SEQ ID KMESPNIKIIRKTVPGIKDLPVACK 20,23,24, NO: 3 KLLEEEGCDIVMALGMPGKAEKDKV 27,28, CAHEASLGLMLAQLMTNKHIIEVFV 109,112, HEDEAKDDAELKILAARRAIEHALN 113,116, VYYLLFKPEYLTRMAGKGLRQGFED 120,124 AGPARE I53-40B MSTINNQLKALKVIPVIAIDNAEDI I53-40B: SEQ ID IPLGKVLAENGLPAAEITFRSSAAV 47,51,54, NO: 4 KAIMLLRSAQPEMLIGAGTILNGVQ 58,74,102 ALAAKEAGATFVVSPGFNPNTVRAC QIIGIDIVPGVNNPSTVEAALEMGL TTLKFFPAEASGGISMVKSLVGPYG DIRLMPTGGITPSNIDNYLAIPQVL ACGGTWMVDKKLVTNGEWDEIARLT REIVEQVNP I53-47A MPIFTLNTNIKATDVPSDFLSLTSR I53-47A: SEQ ID LVGLILSKPGSYVAVHINTDQQLSF 22,25,29, NO: 5 GGSTNPAAFGTLMSIGGIEPSKNRD 72,79,86, HSAVLFDHLNAMLGIPKNRMYIHFV 87 NLNGDDVGWNGTTF I53-47B MNQHSHKDYETVRIAVVRARWHADI I53-47B: SEQ ID VDACVEAFEIAMAAIGGDRFAVDVF 28,31,35, NO: 6 DVPGAYEIPLHARTLAETGRYGAVL 36,39, GTAFVVNGGIYRHEFVASAVIDGMM 131,132, NVQLSTGVPVLSAVLTPHRYRDSAE 135,139, HHRFFAAHFAVKGVEAARACIEILA 146 AREKIAA I53-50A MKMEELFKKHKIVAVLRANSVEEAI I53-50A: SEQ ID EKAVAVFAGGVHLIEITFTVPDADT 25,29,33, NO: 7 VIKALSVLKEKGAIIGAGTVTSVEQ 54,57 CRKAVESGAEFIVSPHLDEEISQFC KEKGVFYMPGVMTPTELVKAMKLGH TILKLFPGEVVGPQEVKAMKGPFPN VKEVPTGGVNLDNVCEWEKAGVLAV GVGSALVKGTPDEVREKAKAFVEKI RGCTE I53-50B MNQHSHKDYETVRIAVVRARWHAEI I53-50B: SEQ ID VDACVSAFEAAMADIGGDRFAVDVE 24,28,36, NO: 8 DVPGAYEIPLHARTLAETGRYGAVL 124,125, GTAFVVNGGIYRHEEVASAVIDGMM 127,128, NVQLSTGVPVLSAVLTPHRYRDSDA 129,131, HTLLFLALFAVKGMEAARACVEILA 132,133, AREKIAA 135,139 I53-51A MFTKSGDDGNTNVINKRVGKDSPLV I53-51A: SEQ ID NFLGDLDELNSFI
Assignees
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Classifications
- C07K14/00Primary
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof · CPC title
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Frequently asked questions
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- What does patent US9630994B2 cover?
- Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using such synthetic nanostructures are disclosed herein.
- Who is the assignee on this patent?
- Univ Washington
- What technology area does this patent fall under?
- Primary CPC classification C07K14/00. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Apr 25 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 2 related publications on this page (citations in our corpus or others sharing the same primary CPC).