Compounds for enhancing the cognitive function

Patent metadata

Field	Value
Publication number	US-9630948-B2
Application number	US-201414909246-A
Country	US
Kind code	B2
Filing date	Jul 28, 2014
Priority date	Aug 2, 2013
Publication date	Apr 25, 2017
Grant date	Apr 25, 2017

Abstract

The invention relates to 2-oxo-1-pyrrolidinyl triazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals for enhancing the cognitive function or to counteract cognitive decline.

First claim

The invention claimed is:

1. A compound of formula (I)

wherein
R 1 is either a 3,4,5-trifluorophenyl or a 3-cyanophenyl group;
R 2 is either cyano or chlorine;
or a tautomer, isomer or salt thereof.

2. The compound according to claim 1 , wherein the R 1 group of formula (I) is in a 4R configuration.

3. The compound according to claim 2 , wherein the R 1 group is a 3,4,5-trifluorophenyl moiety.

4. The compound according to claim 1 , wherein the R 1 group of formula (I) is in a 4S configuration.

5. The compound according to claim 4 , wherein the R 1 group is a 3,4,5-trifluorophenyl moiety.

6. The compound according to claim 1 , wherein the R 1 group is a 3,4,5-trifluorophenyl moiety.

7. The compound according to claim 1 that is
(4R)-1-[(5-chloro-1H-1,2,4-triazol-1-yl)methyl]-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one;
1-{[(4R)-2-oxo-4-(3,4,5-trifluorophenyl)pyrrolidin-1-yl]methyl}-1H-1,2,4-triazole-5-carbonitrile; or
(+)-3-{1-[(5-chloro-1H-1,2,4-triazol-1-yl)methyl]-5-oxopyrrolidin-3-yl}benzonitrile.

8. A pharmaceutical composition containing a compound according to claim 1 together with a suitable pharmaceutically acceptable excipient.

9. A pharmaceutical composition containing a compound according to claim 2 together with a suitable pharmaceutically acceptable excipient.

10. A pharmaceutical composition containing a compound according to claim 7 together with a suitable pharmaceutically acceptable excipient.

11. A method of treating Alzheimer's disease in a human comprising administering to the human an effective amount of a compound according to claim 1 .

12. A method of treating Alzheimer's disease in a human comprising administering to the human an effective amount of a compound according to claim 2 .

13. A method of treating Alzheimer's disease in a human comprising administering to the human an effective amount of a compound according to claim 4 .

14. A method of treating Alzheimer's disease in a human comprising administering to the human an effective amount of a compound according to claim 6 .

15. A method of treating Alzheimer's disease in a human comprising administering to the human an effective amount of a compound according to claim 7 .

16. A method of treating Alzheimer's disease in a human comprising administering to the human an effective amount of a compound according to claim 3 .

17. A method of treating Alzheimer's disease in a human comprising administering to the human an effective amount of a compound according to claim 5 .

Assignees

• Ucb Pharma Sa

Inventors

• Montel Florian
• Jnoff Eric

Classifications

• C07D403/06 Primary

  linked by a carbon chain containing only aliphatic carbon atoms · CPC title