Composition of matter for delivering lipid-soluble materials, and a method for producing it

Patent metadata

Field	Value
Publication number	US-9629888-B2
Application number	US-201113582655-A
Country	US
Kind code	B2
Filing date	Mar 7, 2011
Priority date	Mar 5, 2010
Publication date	Apr 25, 2017
Grant date	Apr 25, 2017

Abstract

This invention describes a novel composition of matter describing a complex comprising leaf protein and a lipophilic substance(s), along with the method of producing it. Delivery of lipid-soluble materials into the body is challenging because they are generally highly insoluble in water and very subject to oxidative degradation. The inventors have found that leaf protein—the water-soluble proteins derived from plant leaves—can efficiently form a complex with lipophilic materials. This leaf protein—lipid-soluble material complex is an effective carrier of lipophilic substances. As such, the leaf protein—lipid-soluble material complex disclosed herein can be used for the delivery of lipophilic vitamins, fatty acids, caretenoids, lipophilic drugs, and other lipophilic materials. This complex can be used to deliver lipophiles in foods, nutritional and dietary supplements, topical compositions and in pharmaceutical products.

First claim

What is claimed is:

1. A freeze-dried or spray-dried powder composition comprising one or more of the vitamins A, D, D2, D3, E or K, bound to a carrier consisting of leaf protein extracted from tobacco, alfalfa or spinach leaves.

2. The freeze-dried or spray-dried powder composition according to claim 1 wherein the composition is a food or food ingredient intended for human consumption.

3. A dietary supplement, nutritional supplement, or nutraceutical comprising the composition of claim 1 .

4. A product intended for consumption by mammals other than humans comprising the composition of claim 1 .

5. A topical composition comprising the freeze-dried or spray-dried composition of claim 1 , and a pharmaceutically acceptable topical carrier.

6. The freeze-dried or spray-dried powder composition according to claim 1 wherein the leaf protein constitutes at least 20% of the composition.

7. The freeze-dried or spray-dried powder composition of claim 1 , wherein said composition is produced by (a) providing a suspension comprising extracted leaf protein in a solvent; (b) combining the leaf protein suspension with one or more of vitamins A, D, D2, D3, E or K (c) allowing the leaf protein to bind with the one or more of vitamins A, D, D2, D3, E or K, and (d) forming the composition into a powder, tablet, capsule, gel-cap, elixir or effervescent tablet.

8. The freeze-dried or spray-dried powder of claim 1 , wherein the leaf protein is crude leaf protein and comprises about 30% of the composition.

Assignees

• Lo Yangming Martin
• Cherian Ansu Elizabeth
• Belson Neil Allen
• Leafpro Llc
• Univ Maryland

Inventors

• Lo Yangming Martin
• Cherian Ansu Elizabeth
• Belson Neil Allen

Classifications

• A61P3/02

  Nutrients, e.g. vitamins, minerals · CPC title

• A23L33/155

  Vitamins A or D · CPC title

• A61K47/46

  Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts · CPC title

• A61K9/19

  lyophilised {, i.e. freeze-dried, solutions or dispersions (lyophilised products with subsequent particle size reduction A61K9/14; granules or pellets made by lyphilisation A61K9/1682; solid oral dosage forms made by lyophilisation A61K9/2095; lyophilisation additives A61K47/00)} · CPC title

• A61K36/81 Primary

  Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed · CPC title