Methods for manipulating phagocytosis mediated by CD47
US-9399682-B2 · Jul 26, 2016 · US
Methods of manipulating phagocytosis mediated by CD47
US9624305B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9624305-B2 |
| Application number | US-201615054891-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 26, 2016 |
| Priority date | Jan 15, 2008 |
| Publication date | Apr 18, 2017 |
| Grant date | Apr 18, 2017 |
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Abstract
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Methods are provided to manipulate phagocytosis of cancer cells, including e.g. leukemias, solid tumors including carcinomas, etc.
First claim
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What is claimed is: 1. A method of treating a human subject for melanoma, the method comprising: administering to a human subject in need thereof an antibody that disrupts the binding of CD47 with SIRPα, at a dose that achieves a depletion in melanoma cancer cells by increasing phagocytosis of cancer cells. 2. The method of claim 1 , wherein the antibody that disrupts the binding of CD47 with SIRPα specifically binds to CD47. 3. The method of claim 1 , wherein the antibody is a humanized or chimeric monoclonal antibody.
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Frequently asked questions
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- What does patent US9624305B2 cover?
- Methods are provided to manipulate phagocytosis of cancer cells, including e.g. leukemias, solid tumors including carcinomas, etc.
- Who is the assignee on this patent?
- Univ Leland Stanford Junior
- What technology area does this patent fall under?
- Primary CPC classification C07K16/2803. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Apr 18 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).