Iron (III) citrate, substantially free of beta-iron hydroxide oxide

Patent metadata

Field	Value
Publication number	US-9624155-B2
Application number	US-201414184062-A
Country	US
Kind code	B2
Filing date	Feb 19, 2014
Priority date	Jan 18, 2011
Publication date	Apr 18, 2017
Grant date	Apr 18, 2017

Abstract

This invention provides a method for producing high-purity iron(III) citrate substantially free of beta-iron hydroxide oxide, high-purity iron(III) citrate substantially free of beta-iron hydroxide oxide, and medical uses thereof.

First claim

The invention claimed is:

1. A method for producing iron(III) citrate comprising:
a step of forming an iron-containing precipitate comprising bringing ferric chloride into contact with sodium hydroxide in an aqueous medium for a duration of two hours or less at a liquid temperature of 0° C. to 10° C. to form an iron-containing precipitate;
a step of generating an aqueous solution of iron(III) citrate comprising bringing citric acid into contact with the iron-containing precipitate in an aqueous medium and generating an aqueous solution of iron(III) citrate via heating; and
a step of precipitating iron(III) citrate comprising bringing the aqueous solution of iron(III) citrate into contact with an organic solvent to precipitate the iron(III) citrate.

2. The method according to claim 1 , wherein the step of generating an aqueous solution of iron(III) citrate comprises bringing citric acid into contact with the iron-containing precipitate at a liquid temperature of 60° C. to 100° C.

3. The method according to claim 1 , wherein the iron-containing precipitate is ferrihydride.

4. The method according to claim 1 , wherein the duration during which ferric chloride is in contact with sodium hydroxide is one hour or less.

5. The method according to claim 1 , wherein the duration during which ferric chloride is in contact with sodium hydroxide is 30 minutes or less.

6. The method according to claim 1 , wherein the step of forming an iron-containing precipitate comprises bringing ferric chloride into contact with sodium hydroxide in an aqueous medium at a liquid temperature of lower than 10° C.

7. The method according to claim 1 , wherein the step of forming an iron-containing precipitate comprises bringing ferric chloride into contact with sodium hydroxide in an aqueous medium at a liquid temperature of 3.5° C. to 8° C.

8. The method according to claim 1 , wherein the step of forming an iron-containing precipitate comprises bringing ferric chloride into contact with sodium hydroxide in an aqueous medium at a liquid temperature of 2.6° C. to 7.5° C.

9. The method according to claim 1 , wherein the step of forming an iron-containing precipitate comprises bringing ferric chloride into contact with sodium hydroxide in an aqueous medium at a liquid temperature of 2.6° C. to 7.6° C.

10. The method according to claim 1 , wherein the step of forming an iron-containing precipitate comprises bringing ferric chloride into contact with sodium hydroxide in an aqueous medium at a liquid temperature of 0° C. to 7.3° C.

11. The method according to claim 1 , wherein the step of forming an iron-containing precipitate comprises bringing ferric chloride into contact with sodium hydroxide in an aqueous medium at a liquid temperature of 1.3° C. to 8.3° C.

12. The method according to claim 1 , wherein the step of forming an iron-containing precipitate comprises bringing ferric chloride into contact with sodium hydroxide in an aqueous medium at a liquid temperature of 2.5° C. to 8.4° C.

13. The method according to claim 1 , wherein the step of forming an iron-containing precipitate comprises bringing ferric chloride into contact with sodium hydroxide in an aqueous medium at a liquid temperature of 1.9° C. to 8.0° C.

14. The method according to claim 1 , wherein the step of forming an iron-containing precipitate comprises bringing ferric chloride into contact with sodium hydroxide in an aqueous medium at a liquid temperature of 1.4° C. to 8.3° C.

15. The method according to claim 1 , wherein the step of forming an iron-containing precipitate comprises bringing ferric chloride into contact with sodium hydroxide in an aqueous medium at a liquid temperature of 2.2° C. to 9.1° C.

16. The method according to claim 1 , wherein the step of forming an iron-containing precipitate comprises bringing ferric chloride into contact with sodium hydroxide in an aqueous medium at a liquid temperature of 3.0° C. to 5.3° C.

Assignees

• Japan Tobacco Inc

Inventors

• Ando Koji
• MANTA Naoki

Classifications

• A61P7/00

  Drugs for disorders of the blood or the extracellular fluid · CPC title

• A61P39/02

  Antidotes · CPC title

• A61P3/00

  Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00) · CPC title

• A61P3/12

  for electrolyte homeostasis · CPC title

• A61P13/12

  of the kidneys · CPC title