Foamable composition combining a polar solvent and a hydrophobic carrier

Patent metadata

Field	Value
Publication number	US-9622947-B2
Application number	US-35085409-A
Country	US
Kind code	B2
Filing date	Jan 8, 2009
Priority date	Oct 25, 2002
Publication date	Apr 18, 2017
Grant date	Apr 18, 2017

Abstract

The present invention relates to a foamable vehicle or cosmetic or pharmaceutical composition, comprising: (1) an organic carrier, at a concentration of 10% to 70% by weight, wherein said organic carrier concurrently comprises: (i) at least one hydrophobic organic carrier, and (ii) at least one polar solvent; (2) at least one surface-active agent; (3) water; and (4) at least one liquefied or compressed gas propellant at a concentration of 3% to 25% by weight of the total composition.
The present invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject, comprising administering the above-mentioned compositions to an afflicted target site.

First claim

What is claimed is:

1. A method of treating or alleviating a disorder, the method comprising:
(a) releasing a foamable composition from a pressurized container to form a breakable foam that is stable at skin temperature and breaks upon application of shear force, said foamable composition comprising at least one liquefied or compressed gas propellant and a therapeutic composition comprising:
(1) a liquid organic carrier, at a concentration of about 10% to about 70% by weight of the therapeutic composition, wherein said liquid organic carrier comprises:
i. at least one liquid hydrophobic organic carrier; and
ii. a liquid polar solvent comprising ethanol and glycerin;
wherein the hydrophobic organic carrier comprises isopropyl myristate;
wherein the weight ratio between the liquid polar solvent and the at least one liquid hydrophobic organic carrier is between about 1:4 and about 4:1;

(2) at least one surface-active agent selected from the group consisting of at least one non-ionic surface-active agent and a mixture of a non-ionic surface-active agent and an ionic surface-active agent, wherein the ratio of the non-ionic surface-active agent to the ionic surface-active agent is about 6:1 or greater than 6:1;
(3) at least one polymeric agent selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent, a phase change agent, and any mixtures of two or more thereof;
(4) water; and
(5) an active agent comprising coal tar or a coal tar extract or a tincture dissolved in all or part of the liquid polar solvent;
wherein the at least one liquefied or compressed gas propellant is at a concentration of about 3% to about 25% by weight of the foamable composition,

(b) applying the breakable foam to a target area having a dermatological or mucosal disorder; the disorder being selected from the group consisting of eczema, psoriasis, pruritis, dandruff, seborrhoeic dermatitis, and combinations of two or more thereof; and
(c) collapsing the breakable foam by applying shear force, wherein the foam is absorbed into the target area.

2. The method of claim 1 , wherein upon release from a container, a shear-sensitive foam having a density of about 0.23 gr/mL or less is produced.

3. The method of claim 1 , further comprising an additional polar solvent selected from the group consisting of a polyol, an alpha hydroxy acid, and any mixtures thereof, and wherein the polyol is selected from the group consisting of propylene glycol, butanediol, butenediol, butynediol, pentanediol, hexanediol, octanediol, neopentyl glycol, 2-methyl-1,3-propanediol, diethylene glycol, triethylene glycol, tetraethylene glycol, dipropylene glycol, dibutylene glycol, 1,2,6-hexanetriol, and any combinations of two or more thereof.

4. The method of claim 3 , wherein the amount of the additional polar solvent is in the range of about 15% to about 60% by weight of the therapeutic composition.

5. The method of claim 3 , wherein the hydrophobic carrier further comprises a silicone oil.

6. The method of claim 5 , wherein the silicone oil is selected from the group consisting of dimethicone, cyclomethicone, and any mixtures thereof.

7. The method of claim 3 , wherein the ratio of the additional polar solvent to the at least one liquid hydrophobic organic carrier is between about 3:4 and about 5:4.

8. The method of claim 1 , wherein the therapeutic composition further comprises a mint comprising a peppermint, a spearmint, or mixtures thereof.

9. The method of claim 1 , wherein the liquid organic carrier further comprises an additional hydrophobic organic carrier selected from the group consisting of an olive oil, corn oil, soybean oil, canola oil, cottonseed oil, coconut oil, sesame oil, sunflower oil, borage seed oil, syzigium aromaticum oil, hempseed oil, herring oil, cod-liver oil, salmon oil, flaxseed oil, wheat germ oil, evening primrose oils, omega-3 fatty acids, omega-6 fatty acids, linoleic acid, gamma-linoleic acid (GLA), eicosapentaenoic acid (EPA) docosahexaenoic acid (DHA), omega-3 oil, omega-6 oil, rosehip oil, tea tree oil, anise oil, basil oil, bergemont oil, camphor oil, cardamom oil, carrot oil, cassia oil, catnip oil, cedarwood oil, citronella oil, clove oil, cypress oil, eucalyptus oil, frankincense oil, garlic oil, ginger oil, grapefruit oil, hyssop oil, jasmine oil, jojova oil, lavender oil, lavandin oil, lemon oil, lime oil, mandarin oil, marjoram oil, myrrh oil, neroli oil, nutmeg oil, orange oil, peppermint oil, petitgrain oil, rosemary oil, sage oil, spearmint oil, star anise oil, tangerine oil, thyme vanilla oil, verbena oil, white clover oil, a liquid triglyceride oil, polyalkyl siloxanes, polyaryl siloxanes, polyalkylaryl siloxanes, polyether siloxane copolymers, polydimethylsiloxanes (dimethicones), poly(dimethylsiloxane)-(diphenyl-siloxane) copolymers, a silicone oil, isopropyl palmitate, isopropyl isostearate, diisopropyl adipate, diisopropyl dimerate, maleated soybean oil, octyl palmitate, cetyl lactate, cetyl ricinoleate, tocopheryl acetate, cetyl acetate, tocopheryl linoleate, wheat germ glycerides, arachidyl propionate, myristyl lactate, decyl oleate, propylene glycol ricinoleate, isopropyl lanolate, pentaerythrityl tetrastearate, neopentylglycol dicaprylate/dicaprate, isononyl isononanoate, isotridecyl isononanoate, myristyl myristate, octyl dodecanol, sucrose esters of fatty acids, octyl hydroxystearate, capric/caprylic triglycerides, and mixtures of any two or more thereof.

10. The method of claim 9 , wherein the propellant is selected from the group consisting of butane, propane, isobutane, and mixtures of any two or more thereof.

11. The method of claim 9 , wherein the additional hydrophobic carrier is selected from the group consisting of isopropyl palmitate, a liquid triglyceride oil, a silicone oil, and any mixtures of two or more thereof.

12. The method of claim 9 , wherein the additional hydrophobic carrier comprises a liquid triglyceride oil.

13. The method of claim 12 , wherein the liquid triglyceride oil is capric-caprylic triglycerides.

14. The method of claim 9 , wherein the additional hydrophobic carrier comprises a mint oil.

15. The method of claim 14 , wherein the mint oil comprises a peppermint oil.

16. The method of claim 1 , wherein the liquid organic carrier further comprises an additional hydrophobic carrier comprising a silicone oil.

17. The method of claim 16 , wherein the silicone oil is selected from the group consisting of dimethicone, cyclomethicone, and any mixtures thereof.

18. The method of claim 16 , wherein the additional hydrophobic carrier further comprises a peppermint oil, a spearmint oil, or mixtures thereof.

19. The method of claim 1 , further comprising an additional polar solvent comprising a polyol and an alpha hydroxy acid.

20. The method of claim 19 , wherein the alpha hydroxy acid is citric acid.

21. The method of claim 1 , wherein the amount of the liquid polar solvent is in the range of about 15% to about 60% by weight of the therapeutic composition.

22. The method of claim 1 , wherein the ionic surface-active agent is selected from the group consisting of an anionic surfactant, a cationic surfactant, a zwitterionic surfactant, an amphoteric surfactant, an ampholytic surfactant, and any mixtures of two or more thereof.

23. The method of claim 1 , wherein the surface-active agent comprises a polyethylene glycol ether.

24. The method of claim 1 , wherein the at least one polyme

Assignees

• Tamarkin Dov
• Friedman Doron
• Eini Meir
• Besonov Alex
• Foamix Pharmaceuticals Ltd

Inventors

• Tamarkin Dov
• Friedman Doron
• Eini Meir
• Besonov Alex

Classifications

• A01N25/16

  Foams · CPC title

• A61Q19/00

  Preparations for care of the skin · CPC title

• A61K8/965

  of inanimate origin · CPC title

• A61K8/375

  the alcohol moiety containing more than one hydroxy group · CPC title

• A61Q19/08

  Anti-ageing preparations · CPC title