System and method for measurement of shear wave speed from multi-directional wave fields

Patent metadata

Field	Value
Publication number	US-9622711-B2
Application number	US-201414398854-A
Country	US
Kind code	B2
Filing date	Apr 25, 2014
Priority date	Jul 19, 2013
Publication date	Apr 18, 2017
Grant date	Apr 18, 2017

Abstract

A system and method for measuring material properties of a medium includes producing a multi-directional wave field in the medium and detecting, with a detection system capable of detecting wave fields propagating in a medium, the multi-directional wave field in at least two spatial dimensions over at least one time instance. The system and method also include determining a lowest wave speed, calculating at least one of wave speed and material properties of the medium, and generating a report indicating the at least one of wave speed and material properties of the medium.

First claim

What is claimed is:

1. A method of measuring material properties of a medium, comprising steps of:
a) producing a multi-directional wave field in the medium;
b) detecting, with a detection system capable of detecting wave fields propagating in the medium, the multi-directional wave field in at least two spatial dimensions over at least one time instance;
c) determining a lowest wave propagation speed from the detecting of step b);
d) calculating at least one of wave speed and material properties of the medium based on the determining of step c); and
e) generating a report indicating the at least one of wave speed and material properties of the medium.

2. The method of claim 1 , wherein the material properties are mechanical properties including at least one of frequency dependent wave speed, storage modulus, and loss modulus.

3. The method of claim 1 , wherein step a) includes applying at least one of external vibrations, physiological motions, and ultrasound radiation force to the medium to produce the multi-directional wave field as a mechanical wave field.

4. The method of claim 1 , wherein step b) includes controlling at least one of an ultrasound system, an optical system, and magnetic resonance imaging (MRI) system to perform the detecting of the wave field.

5. The method of claim 1 , wherein step c) includes calculating a shear wave speed.

6. The method of claim 5 , wherein calculating the shear wave speed includes determining a frequency dependence.

7. The method of claim 1 , wherein step c) includes determining a lowest shear wave speed at a selected temporal frequency, f c , using a wave component in a Fourier-transformed k-f space at f c with a largest distance from the origin of k-f space.

8. The method of claim 7 , wherein the lowest shear wave speed is calculated at a presence of multi-direction shear waves and compressional waves, by:
i) integrating at least one of wave energy and amplitude in k-f space within a circle of changing radius centered at the k-f space origin;
ii) finding a largest radius, k m , where the integrating of step i) increases most rapidly with k; and
iii) calculating the lowest shear wave speed at temporal frequency f c by c s (f c )=f c /k m .

9. The method of claim 1 , wherein step b) includes performing at least one of line-by-line and zone-by-zone sequential detection of the wave field using ultrasound data that is interpolated and aligned in a time grid.

10. A method of producing images of properties of an object, comprising steps of:
a) producing a multi-directional wave field in the object;
b) using an imaging device, acquiring data about the multi-directional wave field in at least two spatial dimensions over at least one time instance;
c) separating the data acquired in step b) into component data propagating in different directions;
d) calculating at least two wave components pointing at different spatial directions from the component data;
e) producing a wave speed map for each propagation direction using the wave components; and
f) combining the wave speed maps to produce at least one of a speed image and material property image for the object.

11. The method of claim 10 , wherein the at least one of the speed image and the material property image indicate at least one of wave speed, storage modulus, and loss modulus.

12. The method of claim 11 , wherein step a) includes producing the multi-directional wave field using at least one of external vibrations, physiological motions, and ultrasound radiation force.

13. The method of claim 10 , wherein the imaging device includes one of an ultrasound system, optical system, and a magnetic resonance imaging (MRI) system.

14. The method of claim 10 , wherein step c) includes using a directional filter in a Fourier transformed k-f domain to separate the data.

15. The method of claim 10 , wherein the wave speed map is a map of shear wave speed.

16. The method of claim 10 , wherein step d) includes calculating the wave components by cross-correlation.

17. The method of claim 16 , wherein the component data includes image data having pixels and the cross-correlation uses multiple pairs of pixels in the image data cross correlated to calculate a wave speed of a center pixel by weighting at least one of a normalized cross-correlation coefficient and a distance of a pair of pixels to the center pixel.

18. The method of claim 10 , wherein step f) includes creating a weighted sum of the wave speed maps for different directions.

19. The method of claim 10 , wherein step f) includes determining one of a minimum and median value of the wave speed maps for different directions.

20. The method of claim 10 , wherein the wave components in step d) include one of delay measured over known distance, measured delay divided by known distance, and known distance divided by measured delay.

21. The method of claim 10 , wherein step d) includes calculating the at least two wave components in orthogonal spatial directions.

22. The method of claim 10 , wherein step e) includes calculating the wave speed map by fitting the wave components to a model.

23. The method of claim 10 , wherein step d) includes imposing at least one of wave speed limits, spatial frequency limits, and temporal frequency limits.

24. The method of claim 10 , wherein step b) includes performing at least one of line-by-line and zone-by-zone sequential detection of the wave field using ultrasound and interpolating and aligning a wave field data in a time grid.

25. The method of claim 10 , wherein a wave field step is produced by generating vibrations thorough at least one of vibrators, loudspeakers, a vibrating bed, and a vibrating chair.

26. The method of claim 10 , where a wave field step is produced using vibrators making impact with mass inertia.

27. A system for measuring material properties of a medium comprising:
a vibration source configured to produce a multi-directional wave field in the medium;
a detector configured to acquire data about the multi-directional wave field in at least two spatial dimensions over a period of time;
a processor configured to:
receive the data from the detection system;
determine a lowest wave propagation speed from the data;
calculate at least one of wave speed and material properties of the medium based on the lowest wave speed; and
generate a report indicating the at least one of wave speed and material properties of the medium.

28. The system of claim 27 wherein the vibration source includes at least one of vibration driver, a loudspeaker, a vibrating bed, and a vibrating chair.

29. A system of producing images of properties of an object comprising:
a vibration source configured to produce a multi-directional wave field in a medium;
a detector configured to acquire data about the multi-directional wave field in at least two spatial dimensions over at least one time instance;
a processor configured to:
a) produce the multi-directional wave field in the object via the vibration source;
b) use an imaging device, to acquire data about the multi-directional wave field in at least two spatial dimensions over at least one time instance;
c) separate the data acquired in step b) into component data propagating in different directions;
d) calculate at least two wave components pointing at different spatial directions from the componen

Assignees

• Mayo Foundation

Inventors

• Zhao Heng
• Song Pengfei
• Urban Matthew W
• Kinnick Randall
• Manduca Armando
• Greenleaf James F
• Chen Shigao

Classifications

• G01S7/52042

  determining elastic properties of the propagation medium or of the reflective target (diagnostic techniques involving the measurement of strain A61B8/485) · CPC title

• A61B8/485 Primary

  involving measuring strain or elastic properties · CPC title

• G01N29/043

  in the interior, e.g. by shear waves · CPC title

• A61B5/7257

  using Fourier transforms · CPC title

• A61B5/4244

  liver · CPC title