Contrast enhanced magnetic resonance angiography with chemical shift encoding for fat suppression

Patent metadata

Field	Value
Publication number	US-9618594-B2
Application number	US-201214112585-A
Country	US
Kind code	B2
Filing date	Apr 17, 2012
Priority date	Apr 21, 2011
Publication date	Apr 11, 2017
Grant date	Apr 11, 2017

Abstract

The invention relates to a method of performing contrast enhanced first pass magnetic resonance angiography, the method comprising: acquiring ( 302 ) magnetic resonance datasets of a region of interest using a single- or multi-echo data acquisition technique, wherein the echo times of the one or multiple echoes are flexible, wherein at the time of the data acquisition the region of interest comprises fat, water and a contrast agent, processing ( 304 ) the datasets using a generalized Dixon water-fat separation technique to eliminate the signal originating from the fat from the background for reconstruction of an image data set.

First claim

The invention claimed is:

1. A method of performing contrast enhanced first pass magnetic resonance angiography, the method comprising:
acquiring magnetic resonance datasets of a region of interest, during a first pass of contrast agent through the region of interest after intravenous injection of the contrast agent, using a multi-echo data acquisition technique using multiple echoes, wherein echo times of the multiple echoes are flexible in that the echoes are not fixed to times at which a water signal originating from water and a fat signal originating from fat are in-phase or opposed-phase, and wherein the region of interest comprises fat, water and the contrast agent during the multi-echo data acquisition; and
processing the datasets using a modified Dixon water-fat separation technique to eliminate the fat signal originating from the fat from background of the region of interest to reconstruct a magnetic resonance angiographic image data set.

2. The method of claim 1 , wherein the multi-echo data acquisition technique is a dual-gradient-echo data acquisition technique and the modified Dixon water-fat separation technique is a two-point Dixon technique with the flexible echo times.

3. The method of claim 1 , wherein the acquisition of the magnetic resonance datasets comprises acquiring first and second echo data at the two different echo times resulting in first and second signal datasets, wherein the first and second echo data are acquired in one time of repetition.

4. The method of claim 3 , wherein the processing of the datasets comprises:
calculating first and second components, or ratios or fractions of the first and second components, from the first and second signal datasets,
deriving two differential phase error candidates from the first and second components,
selecting, for each pixel, one of the derived differential phase error candidates, based on an assumption of smoothness of disturbing field inhomogeneity; and
reconstructing a water image using the selected differential phase error candidate.

5. The method of claim 3 , wherein the first and second signal datasets are first and second acquired complex signal datasets, and wherein the processing of the datasets comprises:
modelling the first and second acquired complex signal datasets by employing a spectral signal model of fat, the modelling of fat resulting in first and second modelled complex signal datasets, the first and second modelled datasets comprising first and second phase errors and the separate signal datasets for water and fat; and
determining from the first and second acquired complex signal datasets and the first and second modelled complex signal datasets the separate signal dataset for water.

6. A computer program product comprising computer executable instructions to perform the method steps as claimed in claim 1 .

7. A magnetic resonance imaging apparatus for performing contrast enhanced first pass magnetic resonance angiography, the apparatus comprising:
a data acquisition system for acquiring magnetic resonance datasets of a region of interest, during a first pass of contrast agent through the region of interest after intravenous injection of the contrast agent, using a multi-echo data acquisition technique using multiple echoes, wherein echo times of the multiple echoes are not fixed to times at which a water signal originating from water and a fat signal originating from fat are in-phase or opposed-phase, and wherein the region of interest comprises fat, water and the contrast agent during the multi-echo data acquisition; and
a reconstruction processor for processing the datasets using a modified Dixon water-fat separation technique to eliminate the fat signals signal originating from the fat from-the background for reconstruction of a magnetic resonance angiographic image data set.

8. The apparatus of claim 7 , wherein the multi-echo data acquisition technique is a dual-gradient-echo data acquisition technique and the modified Dixon water-fat separation technique is a two-point Dixon technique with the flexible echo times.

9. The apparatus of claim 7 , wherein the data acquisition system acquiring the magnetic resonance datasets comprises acquiring first and second echo data at the two different echo times resulting in first and second signal datasets, wherein the first and second echo data are acquired in one time of repetition.

10. The apparatus of claim 9 , wherein the reconstruction processor processing the datasets comprises:
calculating first and second components, or ratios or fractions of the first and second components, from the first and second signal datasets;
deriving two differential phase error candidates from the first and second components,
selecting, for each pixel, one of the derived differential phase error candidates, based on an assumption of smoothness of disturbing field inhomogeneity; and
reconstructing a water image using the selected differential phase error candidate.

11. The apparatus of claim 9 , wherein the first and second signal datasets are first and second acquired complex signal datasets, and wherein the processing of the datasets comprises:
modelling the first and second acquired complex signal datasets by employing a spectral signal model of fat, the modelling of fat resulting in first and second modelled complex signal datasets, the first and second modelled datasets comprising first and second phase errors and the separate signal datasets for water and fat; and
determining from the first and second acquired complex signal datasets and the first and second modelled complex signal datasets the separate signal dataset for water.

Assignees

• Geerts-Ossevoort Liesbeth
• Kooijman Hendrik
• Alberts Eveline
• Eggers Holger
• Koninklijke Philips Nv

Inventors

• Geerts-Ossevoort Liesbeth
• Kooijman Hendrik
• Alberts Eveline
• Eggers Holger

Classifications

• A61B5/02007

  Evaluating blood vessel condition, e.g. elasticity, compliance · CPC title

• G01R33/56563

  caused by a distortion of the main magnetic field B0, e.g. temporal variation of the magnitude or spatial inhomogeneity of B0 (G01R33/56509, G01R33/56518, G01R33/56536 take precedence) · CPC title

• G01R33/4828 Primary

  Resolving the MR signals of different chemical species, e.g. water-fat imaging · CPC title

• G01R33/5601

  involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent · CPC title

• A61B5/055

  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging · CPC title