Deuterated 1-piperazino-3-phenyl indanes for treatment of schizophrenia

Patent metadata

Field	Value
Publication number	US-9617231-B2
Application number	US-201514941800-A
Country	US
Kind code	B2
Filing date	Nov 16, 2015
Priority date	Jun 20, 2011
Publication date	Apr 11, 2017
Grant date	Apr 11, 2017

Abstract

The present invention relates to deuterated 1-piperazino-3-phenyl-indanes and salts thereof with activity at dopamine receptors D 1 and D 2 as well as the 5HT 2 receptors in the central nervous system, to medicaments comprising such compounds as active ingredients, to the use of such compounds in the treatment of diseases in the central nervous system, and to methods of treatment comprising administration of such compounds.

First claim

What is claimed:

1. A hydrochloride salt of the following compound:

2. A hydrobromide salt of the following compound:

3. A hydroiodic salt of the following compound:

Assignees

• H Lundbeck As

Inventors

• Jorgensen Morten
• Andersen Peter Hongaard
• Jensen Klaus Gjervig

Classifications

• A61P25/18

  Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia · CPC title

• A61P25/28

  for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia · CPC title

• A61P25/24

  Antidepressants · CPC title

• A61P25/00

  Drugs for disorders of the nervous system · CPC title

• A61K31/519

  ortho- or peri-condensed with heterocyclic rings · CPC title