Stimuli-responsive material and medical material

Patent metadata

Field	Value
Publication number	US-9616154-B2
Application number	US-201314377051-A
Country	US
Kind code	B2
Filing date	Jan 29, 2013
Priority date	Feb 8, 2012
Publication date	Apr 11, 2017
Grant date	Apr 11, 2017

Abstract

A stimuli-responsive material includes a stimuli-responsive polymer, fibers and water, wherein the fibers have a number average diameter of 1 to 900 nm and are present in the stimuli-responsive material in a dispersed state; and a medical material and an anti-adhesive material, each of which includes a stimuli-responsive material including a stimuli-responsive polymer, fibers and water, wherein the fibers have a number average diameter of 1 to 900 nm and are present in the stimuli-responsive material in a dispersed state.

First claim

The invention claimed is:

1. A stimuli-responsive material comprising:
a) 10 wt % to 50 wt % of a stimuli-responsive polymer,
b) 0.5 wt % to 10 wt % of fibers, and
c) water,
wherein the fibers are dispersed in the stimuli-responsive polymer and water and have a number average diameter of 1 to 900 nm and the stimuli-responsive polymer and the fibers are selected from the following pairings of a polymer and a fiber:
a) a polymer comprising a lactic acid unit (—O—CH(CH 3 )—CO—) and a fiber comprising an ester unit (—CO—O—);
b) a polymer comprising a terephthalic acid-ethylene glycol unit (—O—CO—C 6 H 6 —CO—O—CH 2 CH 2 —) and a fiber comprising an ester unit (—CO—O—);
c) a polymer comprising a nylon 6 unit (—CH 2 CH 2 CH 2 CH 2 CH 2 —CO—NH—) and a fiber comprising an amide unit (—CO—NH—) or a glucosamine unit; and
d) a polymer comprising a glucosamine unit and a fiber comprising a glucosamine unit.

2. The stimuli-responsive material according to claim 1 , wherein a weight ratio (stimuli-responsive polymer/fiber) of the stimuli-responsive polymer to the fiber is 5 to 100.

3. The stimuli-responsive material according to claim 1 , wherein the stimuli-responsive polymer is a temperature-responsive polymer having a lower critical solution temperature.

4. The stimuli-responsive material according to claim 1 , wherein a difference of Solubility Parameters of basic chemical structure of the stimuli-responsive polymer and the fiber is 0 to 5.

5. The stimuli-responsive material according to claim 1 , wherein the stimuli-responsive polymer comprises a lactic acid unit and the fiber is a polylactic acid.

6. The stimuli-responsive material according to claim 1 , wherein the fiber has a fiber length of 0.01 to 10.0 mm.

7. The stimuli-responsive material according to claim 1 , wherein a ratio (L/D) of a fiber length to a fiber diameter is 200 to 100,000.

8. The stimuli-responsive material according to claim 1 , further comprising a surfactant having a number average molecular weight of 10,000 to 100,000.

9. The stimuli-responsive material according to claim 1 , wherein the stimuli-responsive material is a temperature responsive material having a low critical solution temperature.

10. The stimuli-responsive material according to claim 1 , wherein a storage elastic modulus is less than 100 Pa at 25° C. and a maximum storage elastic modulus is 100 to 50,000 Pa within 30 to 60° C.

11. A medical material comprising the stimuli-responsive material according to claim 1 .

12. An anti-adhesive material comprising the stimuli-responsive material according to claim 1 .

Assignees

• Toray Industries

Inventors

• Horiguchi Tomoyuki
• Takeuchi Kosaku
• Naruse Yoshihiro
• Tanahashi Kazuhiro
• Yokoe Makito
• Yamashita Kohei

Classifications

• A61P41/00

  Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution · CPC title

• D01F8/12

  with at least one polyamide as constituent · CPC title

• D01D5/36

  Matrix structure; Spinnerette packs therefor · CPC title

• A61L15/42

  Use of materials characterised by their function or physical properties (liquid bandages A61L26/00) · CPC title

• C08L33/26

  Homopolymers or copolymers of acrylamide or methacrylamide · CPC title