Stable injectable compositions of glp-2 peptide
US-2024415933-A1 · Dec 19, 2024 · US
US9616108B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9616108-B2 |
| Application number | US-8112308-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 10, 2008 |
| Priority date | Jan 8, 2007 |
| Publication date | Apr 11, 2017 |
| Grant date | Apr 11, 2017 |
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This invention relates to methods of treating and ameliorating congenital and neonatal hyperinsulinism and post-prandial hypoglycemia, comprising the step of administering an antagonist of the Glucagon-Like Peptide-1 (GLP-1) receptor, e.g. a GLP-1 fragment or analog thereof.
Opening claim text (preview).
What is claimed is: 1. A method of treating congenital hyperinsulinism in a subject having congenital hyperinsulinism associated with or due to a loss of function mutation in the K ATP channel, the method comprising the step of administering to said subject an effective amount of a peptide, wherein the amino acid sequence of the peptide consists of the amino sequence set forth in SEQ ID NO: 1. 2. The method of claim 1 , wherein said congenital hyperinsulinism is associated with a mutation in a gene encoding a sulfonylurea receptor (SUR-1). 3. The method of claim 1 , wherein said congenital hyperinsulinism is associated with a mutation in a gene encoding a Kir6.2. 4. The method of claim 1 , whereby administering is via intravenous, parenteral, oral, intraperitoneal, subcutaneous administration or a combination thereof. 5. The method of claim 1 , wherein said peptide is administered subcutaneously. 6. The method of claim 1 , wherein said peptide is administered intravenously. 7. The method of claim 1 , wherein said peptide is administered by infusion.
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