Methods and compositions for treating hypoglycemic disorders

US9616108B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-9616108-B2
Application numberUS-8112308-A
CountryUS
Kind codeB2
Filing dateApr 10, 2008
Priority dateJan 8, 2007
Publication dateApr 11, 2017
Grant dateApr 11, 2017

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  1. Title

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  2. Abstract

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  3. Assignees and inventors

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  4. Key dates

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  5. First independent claim

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  6. CPC / IPC classifications

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  7. Citations and related patents

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Abstract

Official abstract text for this publication.

This invention relates to methods of treating and ameliorating congenital and neonatal hyperinsulinism and post-prandial hypoglycemia, comprising the step of administering an antagonist of the Glucagon-Like Peptide-1 (GLP-1) receptor, e.g. a GLP-1 fragment or analog thereof.

First claim

Opening claim text (preview).

What is claimed is: 1. A method of treating congenital hyperinsulinism in a subject having congenital hyperinsulinism associated with or due to a loss of function mutation in the K ATP channel, the method comprising the step of administering to said subject an effective amount of a peptide, wherein the amino acid sequence of the peptide consists of the amino sequence set forth in SEQ ID NO: 1. 2. The method of claim 1 , wherein said congenital hyperinsulinism is associated with a mutation in a gene encoding a sulfonylurea receptor (SUR-1). 3. The method of claim 1 , wherein said congenital hyperinsulinism is associated with a mutation in a gene encoding a Kir6.2. 4. The method of claim 1 , whereby administering is via intravenous, parenteral, oral, intraperitoneal, subcutaneous administration or a combination thereof. 5. The method of claim 1 , wherein said peptide is administered subcutaneously. 6. The method of claim 1 , wherein said peptide is administered intravenously. 7. The method of claim 1 , wherein said peptide is administered by infusion.

Assignees

Inventors

Classifications

  • for hyperglycaemia, e.g. antidiabetics · CPC title

  • A61K38/26Primary

    Glucagons · CPC title

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Frequently asked questions

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What does patent US9616108B2 cover?
This invention relates to methods of treating and ameliorating congenital and neonatal hyperinsulinism and post-prandial hypoglycemia, comprising the step of administering an antagonist of the Glucagon-Like Peptide-1 (GLP-1) receptor, e.g. a GLP-1 fragment or analog thereof.
Who is the assignee on this patent?
Stoffers Doris, De Leon Diva D, Stanley Charles, and 2 more
What technology area does this patent fall under?
Primary CPC classification A61K38/26. Mapped technology areas include Human Necessities.
When was this patent published?
Publication date Tue Apr 11 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).