Solid lipid nanoparticles (I)

Patent metadata

Field	Value
Publication number	US-9616001-B2
Application number	US-201414775020-A
Country	US
Kind code	B2
Filing date	Mar 14, 2014
Priority date	Mar 15, 2013
Publication date	Apr 11, 2017
Grant date	Apr 11, 2017

Abstract

The present invention relates to new (foodgrade) solid lipid nanoparticles, as well as the production of such solid lipid nanoparticles and the use of them.

First claim

The invention claimed is:

1. Solid lipid nanoparticles comprising
(a) a core comprising,
(a1) a lipid phase in a solid state, and
(a2) up to 60 wt-%, based on the total weight of the solid lipid nanoparticles, of at least one lipophilic and/or amphiphilic active ingredient, and

(b) an emulsifier system comprising:
(b1) at least one emulsifier;
(b2) 0.1-30 wt-%, based on the total weight of the solid lipid nanoparticles, of at least one co-emulsifier selected from the group consisting of polysorbates, phospholipids, stearoyl-2-lactylat and citric ester of mono and di-glycerides, and
(b3) 0.1-30 wt. %, based on the total weight of the solid lipid nanoparticles, of at least one saponin compound, wherein

the solid lipid nanoparticles are substantially spherical with a diameter of 50-300 nm.

2. The solid lipid nanoparticles according to claim 1 , wherein the emulsifier system has a crystallization point which is lower than a crystallization point of the core.

3. The solid lipid nanoparticles according to claim 1 , wherein the lipid phase is at least one oil selected from the group consisting of triglycerides, partial glycerides, fatty acids, steroids and waxes.

4. The solid lipid nanoparticles according to claim 1 , wherein the lipophilic and/or amphiphilic active ingredient is selected from the group consisting of antimicrobials, antioxidants, polyphenols, vitamins, polyunsaturated fatty acids (PUFAs) and dyestuffs.

5. The solid lipid nanoparticles according to claim 1 , wherein the saponin is Quillaia saponaria.

6. The solid lipid nanoparticles according to claim 1 wherein the at least one saponin is present in a concentration of 0.5-20 wt-%, based on the total weight of the solid lipid nanoparticles.

7. The solid lipid nanoparticles according to claim 1 , wherein the at least one co-emulsifier is present in a concentration of 0.5-20 wt-%, based on the total weight of the solid lipid nanoparticles.

8. A food product, feed product or personal care product comprising the solid lipid nanoparticles as claimed in claim 1 .

Assignees

• Dsm Ip Assets Bv
• Dsm Ip Assets Bv

Inventors

• Weiss Jochen
• Schweiggert Christiane
• Leuenberger Bruno
• Novotny Markus
• Tedeschi Concetta
• Kessler Anne

Classifications

• A61K8/9789

  Magnoliopsida [dicotyledons] · CPC title

• A61K8/671

  Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal · CPC title

• A61K2800/10

  General cosmetic use · CPC title

• A23P10/30

  Encapsulation of particles, e.g. foodstuff additives · CPC title

• A61K2800/52

  Stabilizers · CPC title