Remote monitoring of vital signs

Patent metadata

Field	Value
Publication number	US-9615749-B2
Application number	US-201214240291-A
Country	US
Kind code	B2
Filing date	Aug 16, 2012
Priority date	Aug 22, 2011
Publication date	Apr 11, 2017
Grant date	Apr 11, 2017

Abstract

A method of remote monitoring of vital signs by detecting the PPG signal in an image of a subject taken by a video camera such as a webcam. The PPG signal is identified by auto-regressive analysis of ambient light reflected from a region of interest on the subject's skin. Frequency components of the ambient light and aliasing artefacts resulting from the frame rate of the video camera are cancelled by auto-regressive analysis of ambient light reflected from a region of interest not on the subject's skin, e.g. in the background. This reveals the spectral content of the ambient light allowing identification of the subject's PPG signal. Heart rate, oxygen saturation and breathing rate are obtained from the PPG signal. The values can be combined into a wellness index based on a statistical analysis of the values.

First claim

The invention claimed is:

1. A method of suppressing ambient light interference in a photoplethysmographic (PPG) image signal, the method comprising:
imaging a first region of interest on a skin of a subject using a video camera to obtain a PPG image signal, wherein the PPG image signal comprises periodic intensity variations corresponding to ambient light reflected from the region of interest;
imaging a first reference region of interest not on the skin using the video camera to obtain a reference signal;
spectrally analyzing, via a computer, the reference signal using a first auto-regressive (AR) all pole model to identify poles corresponding to spectral components in the first AR all pole model for the reference signal; and
spectrally analyzing, via a computer, the PPG image signal using a second auto-regressive (AR) all pole model to identify poles corresponding to spectral components in the second AR all pole model for the PPG image signal and removing poles in the second AR all pole model corresponding to the spectral components of the reference signal to suppress the ambient light interference;
estimating, via the computer, a first vital-sign of the subject based on a remaining portion of the second AT all pole model and after removal of the selected ones of the poles from the second AR all pole model corresponding to the spectral components of the reference signal; and
storing, displaying or transmitting, via the computer, the estimated first vital sign.

2. The method according to claim 1 , wherein the reference signal and PPG image signal are output signals from (i) at least one of red, green and blue channels of the video camera, or (ii) an infrared channel of another camera.

3. The method according to claim 1 , further comprising:
imaging a first plurality of regions of interest on the skin, wherein the first plurality of regions of interest include the first region of interest; and
imaging a second plurality of regions of interest, wherein the second plurality of regions of interest comprise the reference region of interest and other reference regions of interest.

4. The method according to claim 3 , wherein each of the first plurality of regions of interest and each of the second plurality of regions of interest is centered on a single camera pixel.

5. The method according to claim 1 , further comprising obtaining vital sign data from remaining components of the PPG image signal.

6. The method according to claim 1 , wherein:
the reference signal and the PPG image signal are each analyzed using a plurality of models having respective orders; and
the plurality of models comprise the first AR all pole model and the second AR all pole model.

7. The method according to claim 6 , wherein the plurality of models have respectively orders 8 to 20.

8. The method according to claim 6 , further comprising averaging the spectral components of the reference signal and the PPG image signal over different order models, wherein the different order models include the first AR all pole model and the second AR all pole model.

9. The method according to claim 1 , further comprising obtaining a measurement of a heart rate of the subject by identifying a pole in the PPG image signal as representing the heart rate, which is not present in the reference signal.

10. The method according to claim 9 , wherein the measurement of the heart rate is obtained by identifying a pole corresponding to a spectral component and having a frequency between 0.67 Hz and 4 Hz.

11. A method according to claim 9 , further comprising obtaining a measurement of a blood oxygen saturation level of the subject by obtaining a ratio of intensity of light at two different wavelengths reflected from the region of interest on the skin, wherein the intensity of light is obtained from a magnitude of the pole identified as representing the heart rate.

12. A method according to claim 11 , wherein the two different wavelengths are red and green wavelengths detected by the video camera.

13. A method according to claim 11 , wherein the two different wavelengths comprise (i) a red wavelength detected by the video camera, and (ii) an infrared wavelength detected by a second video camera.

14. A non-transistory computer readable storage medium storing software executable by at least one of a processor and a controller, wherein the software includes code adapted to:
execute the method of claim 1 ; and
obtain a measurement of one or more vital signs of the subject by PPG imaging the subject, wherein the one or more vital signs include the estimated first vital sign, and wherein ambient light interference associated with the PPG imaging is suppressed by execution of the method of claim 1 .

15. A method of measuring one or more vital signs including the first vital sign, the method comprising:
PPG imaging the subject using the video camera including suppressing the ambient light interference by performing the method of claim 1 ; and
performing a facial recognition process on an image of the subject obtained by the video camera to link the identity of the subject to the one or more vital signs.

16. A method according to claim 1 , further comprising obtaining a measurement of a breathing rate of the subject by low-pass filtering and downsampling the PPG image signal before spectrally analyzing the PPG image signal using a third AR all pole model.

Assignees

• Clifton David Andrew
• Montoya Mauricio Christian Villarroel
• Tarassenko Lionel
• Isis Innovation

Inventors

• Clifton David Andrew
• Montoya Mauricio Christian Villarroel
• Tarassenko Lionel

Classifications

• G06F2218/20

  by applying autoregressive analysis · CPC title

• G06T2207/30076

  Plethysmography · CPC title

• A61B5/0205 Primary

  Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition · CPC title

• A61B5/14551

  for measuring blood gases · CPC title

• A61B5/0816

  Measuring devices for examining respiratory frequency (measuring frequency of electric signals G01R23/00) · CPC title