Ultra-fast magnetic field for electron paramagnetic resonance imaging used in monitoring dose from proton or hadron therapy

Patent metadata

Field	Value
Publication number	US-9612308-B2
Application number	US-201213475005-A
Country	US
Kind code	B2
Filing date	May 18, 2012
Priority date	Jun 20, 2008
Publication date	Apr 4, 2017
Grant date	Apr 4, 2017

Abstract

Instrumentation and methodologies are provided that enable the direct measurement of free radicals generated in patients as a result of radiation therapy through the use of proton beams and other forms of ionizing radiation. As a result, in accordance with at least one disclosed embodiment, the instrumentation and methodologies may be used in conjunction with radiation therapy to detect, monitor and/or control generation of free radicals in cancerous tissue during such radiation therapy.

First claim

What is claimed is:

1. A method for applying electron paramagnetic resonance imaging to living biological tissue exposed to ionizing radiation, the method comprising:
imposing a magnetic field on the living biological tissue while imposing gradient pulses on the biological tissue; and
obtaining data indicating an amount of free radicals in the living biological tissue generated as a result of the exposure to ionizing radiation,
wherein one or more magnetic fields are applied in at least one pulse, and with a ramp of the at least one pulse lasting less than 10 microseconds.

2. The method of claim 1 , wherein the imposed magnetic field is a static magnetic field.

3. The method of claim 1 , wherein the imposed magnetic field is a quasi-static magnetic field.

4. The method of claim 1 , wherein the imposed magnetic field is a dynamic magnetic field.

5. The method of claim 1 , further comprising monitoring distribution of dose or exposure in the living biological tissue.

6. The method of claim 1 , further comprising monitoring an effect of exposure to ionizing radiation in the living biological tissue.

7. The method of claim 1 , wherein the one or magnetic fields are rapidly changing and applied in pulse sequences for electron paramagnetic resonance imaging, and wherein the rapidly changing magnetic fields have rise-times and fall-times of less than 10 microseconds.

8. The method of claim 1 , with a duration of the at least one pulse being less than 10 microseconds.

9. The method of claim 1 , wherein the ionizing radiation is proton therapy.

10. The method of claim 1 , wherein the ionizing radiation is hadron therapy.

11. The method of claim 1 , wherein a sub-second duration of the entire pulse sequence is required to form an image.

12. The method of claim 1 , further comprising using the data obtained from monitoring dose to adjust a next administered ionizing radiation dose.

13. A method for applying electron paramagnetic resonance imaging to living biological tissue exposed to ionizing radiation, the method comprising:
imposing a magnetic field on the living biological tissue while imposing gradient pulses on the biological tissue; and
monitoring distribution of dose or exposure of the ionizing radiation in the living biological tissue,
wherein one or more magnetic fields are applied in at least one pulse, and with a ramp of the at least one pulse lasting less than 10 microseconds.

14. The method of claim 13 , wherein the imposed magnetic field is a static magnetic field.

15. The method of claim 13 , wherein the imposed magnetic field is a quasi-static magnetic field.

16. The method of claim 13 , wherein the imposed magnetic field is a dynamic magnetic field.

17. The method of claim 13 , further comprising monitoring an effect of exposure to ionizing radiation in the living biological tissue.

18. The method of claim 13 , wherein the one or magnetic fields are rapidly changing and applied in pulse sequences for electron paramagnetic resonance imaging, and wherein the rapidly changing magnetic fields have rise-times and fall-times of less than 10 microseconds.

19. The method of claim 13 , with a duration of the at least one pulse being less than 10 microseconds.

20. The method of claim 13 , wherein the ionizing radiation is proton therapy.

21. The method of claim 13 , wherein the ionizing radiation is hadron therapy.

22. The method of claim 13 , wherein a sub-second duration of the entire pulse sequence is required to form an image.

23. The method of claim 13 , further comprising using the data obtained from monitoring dose to adjust a next administered ionizing radiation dose.

Assignees

• Weinberg Irving N
• Fricke Stanley Thomas
• Weinberg Medical Physics Inc

Inventors

• Weinberg Irving N
• Fricke Stanley Thomas

Classifications

• A61N2005/1087

  Ions; Protons · CPC title

• A61N5/1071

  for verifying the dose delivered by the treatment plan · CPC title

• A61N2005/1055

  using magnetic resonance imaging [MRI] · CPC title

• G01R33/4808

  Multimodal MR, e.g. MR combined with positron emission tomography [PET], MR combined with ultrasound or MR combined with computed tomography [CT] · CPC title

• G01R33/60 Primary

  using electron paramagnetic resonance (G01R33/24, G01R33/62 take precedence) · CPC title