Radiolabeled quinazoline derivatives
US-2015368230-A1 · Dec 24, 2015 · US
Compound suitable for detection of vesicular acetylcholine transporter
US9610369B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9610369-B2 |
| Application number | US-201414781994-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 2, 2014 |
| Priority date | Apr 5, 2013 |
| Publication date | Apr 4, 2017 |
| Grant date | Apr 4, 2017 |
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- Title
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Abstract
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The present invention provides a compound represented by formula (I), wherein in formula (I), R 1 represents CH 3 , F, (CH 2 ) n —F, NH—(CH 2 ) n —F, O—(CH 2 ) n —F or S—(CH 2 ) n —F, and n represents an integer of 1 to 3.
First claim
Opening claim text (preview).
The invention claimed is: 1. A compound represented by formula (I): wherein in formula (I), R 1 represents CH 3 , F, (CH 2 ) n —F, NH—(CH 2 ) n —F, O—(CH 2 ) n or S—(CH 2 ) n —F, and n represents an integer of 1 to 3. 2. The compound according to claim 1 , wherein R 1 is 11 CH 3 , 18 F, (CH 2 ) n — 18 F, —(CH 2 ) n — 18 F, O—(CH 2 ) n — 18 F or S—(CH 2 ) n — 18 F, and n represents an integer of 1 to 3. 3. The compound according to claim 1 , represented by any one of formulas (II) to (V): 4. The compound according to claim 3 , wherein CH 3 is 11 CH 3 . 5. A compound represented by formula (VI): wherein in formula (VI), R 2 represents OH, SH, or an organic group containing B. 6. A vesicular acetylcholine transporter detection reagent, containing a compound according to claim 1 . 7. A diagnostic agent for Alzheimer's disease, containing a compound according to claim 1 . 8. The vesicular acetylcholine transporter detection reagent according to claim 6 , wherein the compound is a compound represented by either one of formulas (IV) and (V): 9. The diagnostic agent for Alzheimer's disease according to claim 7 , wherein the compound is a compound represented by either one of formulas (IV) and (V): 10. A vesicular acetylcholine transporter detection reagent, containing a compound according to claim 2 . 11. A vesicular acetylcholine transporter detection reagent, containing a compound according to claim 3 . 12. A vesicular acetylcholine transporter detection reagent, containing a compound according to claim 4 . 13. A diagnostic agent for Alzheimer's disease, containing a compound according to claim 2 . 14. A diagnostic agent for Alzheimer's disease, containing a compound according to claim 3 . 15. A diagnostic agent for Alzheimer's disease, containing a compound according to claim 4 .
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Classifications
Heterocyclic compounds · CPC title
with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings · CPC title
- A61K51/0459Primary
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine · CPC title
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- What does patent US9610369B2 cover?
- The present invention provides a compound represented by formula (I), wherein in formula (I), R 1 represents CH 3 , F, (CH 2 ) n —F, NH—(CH 2 ) n —F, O—(CH 2 ) n —F or S—(CH 2 ) n —F, and n represents an integer of 1 to 3.
- Who is the assignee on this patent?
- Hamamatsu Photonics Kk, Nard Institute Ltd
- What technology area does this patent fall under?
- Primary CPC classification A61K51/0459. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Apr 04 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).