Method of modulating membrane potential of a cell

Patent metadata

Field	Value
Publication number	US-9610263-B2
Application number	US-33764208-A
Country	US
Kind code	B2
Filing date	Dec 18, 2008
Priority date	Dec 19, 2007
Publication date	Apr 4, 2017
Grant date	Apr 4, 2017

Abstract

Provided herein are methods of modulating membrane potential of a cell membrane using self-assembling compounds. Also provided herein are methods of regulating a natural voltage-dependent ion channel in a cell membrane using the self-assembling compounds disclosed herein. Further provided herein are methods of treating, preventing and/or managing a disease that is related to the abnormal membrane potential responses by using the self-assembling compounds disclosed herein.

First claim

What is claimed is:

1. A method of modulating membrane potential of a cell membrane comprising:
forming a synthetic chloride ion channel in the cell membrane;
wherein the synthetic ion channel is formed by a plurality of molecules of a self-assembling compound having formula:

wherein D is CH(R) wherein R is:
(1) C 1-6 alkyl optionally substituted with NH 2 ;
(2) (C 1-6 alkyl)C(═O)(OC 1-6 alkyl);
(3) (C 1-6 alkyl)S(C 1-6 alkyl);
(4) (C 0-6 alkyl)phenyl; or
(5) indolyl;
X is C 1-20 alkyl; and
k is 1.

2. The method of claim 1 , wherein the synthetic ion channel is formed by a plurality of molecules of a self-assembling compound having formula

wherein X is C 1-20 alkyl.

3. The method of claim 1 , wherein X is isobutyl.

4. The method of claim 2 , wherein the self-assembling compound is

or a salt or stereoisomer thereof.

5. The method of claim 2 , in which the self-assembling compound is:

or any salt or stereoisomer of any thereof.

Assignees

• Yang Dan
• Li Xiang
• Shen Bing
• Yao Xiao-Qiang
• Versitech Ltd
• Univ Hong Kong Chinese

Inventors

• Yang Dan
• Li Xiang
• Shen Bing
• Yao Xiao-Qiang

Classifications

• A61P9/12

  Antihypertensives · CPC title

• A61P25/00

  Drugs for disorders of the nervous system · CPC title

• A61P27/00

  Drugs for disorders of the senses · CPC title

• A61P25/14

  for treating abnormal movements, e.g. chorea, dyskinesia · CPC title

• A61P25/08

  Antiepileptics; Anticonvulsants · CPC title